A hydrogel system for drug loading toward the synergistic application of reductive/heat-sensitive drugs

作者全名："Cai, Yucen; Fu, Xiaoxue; Zhou, Yingjuan; Lei, Lin; Wang, Jiajia; Zeng, Weinan; Yang, Zhangyou"

作者地址："[Cai, Yucen; Zhou, Yingjuan; Lei, Lin; Wang, Jiajia; Yang, Zhangyou] Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing Key Lab Pharmaceut Metab Res,Res Ctr, Chongqing 400016, Peoples R China; [Fu, Xiaoxue; Zeng, Weinan] Sichuan Univ, West China Hosp, Dept Orthoped Surg, Chengdu, Peoples R China; [Fu, Xiaoxue; Zeng, Weinan] Sichuan Univ, West China Hosp, Orthoped Res Inst, Chengdu 610041, Peoples R China"

通信作者："Yang, ZY (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing Key Lab Pharmaceut Metab Res,Res Ctr, Chongqing 400016, Peoples R China.; Zeng, WA (通讯作者)，Sichuan Univ, West China Hosp, Dept Orthoped Surg, Chengdu, Peoples R China.; Zeng, WA (通讯作者)，Sichuan Univ, West China Hosp, Orthoped Res Inst, Chengdu 610041, Peoples R China."

来源：JOURNAL OF CONTROLLED RELEASE

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001072254000001

JCR分区：Q1

影响因子：10.8

年份：2023

卷号：362

期号：　

开始页：409

结束页：424

文献类型：Article

关键词：Hydrogel; Reducing/heat-sensitive drug; Oxygen -loading; Diabetic wound; Synergistic application

摘要："The preparation of hydrogels as drug carriers via radical-mediated polymerization has significant prospects, but the strong oxidizing ability of radicals and the high temperatures generated by the vigorous reactions limits the loading for reducing/heat-sensitive drugs. Herein, an applicable hydrogel synthesized by radical-mediated polymerization is reported for the loading and synergistic application of specific drugs. First, the desired sol is obtained by polymerizing functional monomers using a radical initiator, and then tannic-acid-assisted specific drug mediates sol-branched phenylboric acid group to form the required functional hydrogel (New-gel). Compared with the conventional single-step radical-mediated drug-loading hydrogel, the New-gel not only has better chemical/physical properties but also efficiently loads and releases drugs and maintains drug activity. Particularly, the New-gel has excellent loading capacity for oxygen, and exhibits significant practical therapeutic effects for diabetic wound repair. Furthermore, owing to its high light transmittance, the New-gel synergistically promotes the antibacterial effect of photosensitive drugs. This gelation strategy for loading drugs has further promising biomedical applications."

基金机构：National Natural Science Foundation of China [82272483]; Natural Science Foun-dation of Chongqing [CSTB2022NSCQ-MSX1084]; Youth Talent Foundation at College of Pharmacy (Chongqing Medical University) [YXY2019QNGD1]

基金资助正文："This work was financially supported by the National Natural Science Foundation of China (Grant No. 82272483) , the Natural Science Foun-dation of Chongqing (Grant No. CSTB2022NSCQ-MSX1084) , and the Youth Talent Foundation at College of Pharmacy (Chongqing Medical University) (Grant No. YXY2019QNGD1) ."