Long-Term Impacts of Preeclampsia on the Cardiovascular System of Mother and Offspring

作者全名："Yang, Chuyu; Baker, Philip N.; Granger, Joey P.; Davidge, Sandra T.; Tong, Chao"

作者地址："[Yang, Chuyu; Tong, Chao] Chongqing Med Univ, Affiliated Hosp 1, State Key Lab Maternal & Fetal Med Chongqing Munic, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Yang, Chuyu; Baker, Philip N.; Tong, Chao] Minist Educ, Int Collaborat Lab Reprod & Dev, Chongqing, Peoples R China; [Baker, Philip N.] Univ Leicester, Coll Life Sci, Leicester, England; [Granger, Joey P.] Univ Mississippi Med Ctr, Dept Physiol & Biophys, Jackson, MS USA; [Davidge, Sandra T.] Univ Alberta, Dept Obstet & Gynecol, 232 HMRC, Edmonton, AB T6G 2S2, Canada; [Davidge, Sandra T.] Univ Alberta, Women & Childrens Hlth Res Inst, 232 HMRC, Edmonton, AB T6G 2S2, Canada"

通信作者："Tong, C (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, State Key Lab Maternal & Fetal Med Chongqing Munic, 1 Youyi Rd, Chongqing 400016, Peoples R China.; Davidge, ST (通讯作者)，Univ Alberta, Dept Obstet & Gynecol, 232 HMRC, Edmonton, AB T6G 2S2, Canada.; Davidge, ST (通讯作者)，Univ Alberta, Women & Childrens Hlth Res Inst, 232 HMRC, Edmonton, AB T6G 2S2, Canada."

来源：HYPERTENSION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001072405400005

JCR分区：Q1

影响因子：6.9

年份：2023

卷号：80

期号：9

开始页：1821

结束页：1833

文献类型：Review

关键词：cardiovascular diseases; child health; maternal health; preeclampsia; pregnancy

摘要："Preeclampsia is a pregnancy-specific complication that is associated with an increased postpartum risk of cardiovascular disease (CVD) in both women and their offspring, although the underlying mechanisms have yet to be fully elucidated. Nevertheless, differential methylation of cytosine-phosphate-guanosine islands and alterations in the expression of microRNA, associated with an elevated risk of CVD, have been observed in women and their children following preeclampsia. Among this specific population, genetic and epigenetic factors play crucial roles in the development of CVD in later life. A series of biomolecules involved in inflammation, oxidative stress, and angiogenesis may link pregnancy vascular bed disorders in preeclampsia to the pathogenesis of future CVD and thus could be valuable for the prediction and intervention of long-term CVD in women with a history of preeclampsia and their offspring. Here, we present insights into the cardiovascular structure and functional changes of women with a history of preeclampsia and their offspring. With a focus on various underlying mechanisms, the conclusions from this review are expected to provide more potential diagnostics and treatment strategies for clinical practice."

基金机构："National Key Ramp;D Program of China; National Natural Science Foundation of China [2022YFC2702400, 81871189]; [82071675]"

基金资助正文：This study was supported by the National Key R & amp;D Program of China (2022YFC2702400) and the National Natural Science Foundation of China (81871189 and 82071675).