Elucidating the molecular mechanisms of ozone therapy for neuropathic pain management by integrated transcriptomic and metabolomic approach

作者全名："Yang, Xiaolan; Chen, Chaoming; Wang, Keyang; Chen, Min; Wang, Yong; Chen, Zhengping; Zhao, Wang; Ou, Shu"

作者地址："[Yang, Xiaolan; Chen, Chaoming; Wang, Keyang; Chen, Min; Wang, Yong; Chen, Zhengping; Ou, Shu] Chongqing Med Univ, Fengjie Peoples Hosp, Affiliated Hosp 2, Dept Neurol,Fengjie Branch, Chongqing, Peoples R China; [Zhao, Wang] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China"

通信作者："Ou, S (通讯作者)，Chongqing Med Univ, Fengjie Peoples Hosp, Affiliated Hosp 2, Dept Neurol,Fengjie Branch, Chongqing, Peoples R China."

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001072696200001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ozone therapy; neuropathic pain; transcriptomics; metabolomics; mechanism of action; multi-omics

摘要："Introduction: Neuropathic pain remains a prevalent and challenging condition to treat, with current therapies often providing inadequate relief. Ozone therapy has emerged as a promising treatment option; however, its mechanisms of action in neuropathic pain remain poorly understood.Methods: In this study, we investigated the effects of ozone treatment on gene expression and metabolite levels in the brainstem and hypothalamus of a rat model, using a combined transcriptomic and metabolomic approach.Results: Our findings revealed significant alterations in key genes, including DCST1 and AIF1L, and metabolites such as Aconitic acid, L-Glutamic acid, UDP-glucose, and Tyrosine. These changes suggest a complex interplay of molecular pathways and region-specific mechanisms underlying the analgesic effects of ozone therapy.Discussion: Our study provides insights into the molecular targets of ozone treatment for neuropathic pain, laying the groundwork for future research on validating these targets and developing novel therapeutic strategies."

基金机构：This research was funded by the Talent Fund of the Fengjie People's Hospital.

基金资助正文：This research was funded by the Talent Fund of the Fengjie People's Hospital.