Single-cell RNA sequencing in juvenile idiopathic arthritis

作者全名："Luo, Xiwen; Tang, Xuemei"

作者地址："[Luo, Xiwen; Tang, Xuemei] Chongqing Med Univ, Childrens Hosp, Dept Rheumatol & Immunol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Tang, Xuemei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing Key Lab Child Infect & Immun,Childrens H, Chongqing 400014, Peoples R China"

通信作者："Tang, XM (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Rheumatol & Immunol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001072951900001

JCR分区：Q1

影响因子：6.9

年份：2024

卷号：11

期号：2

开始页：633

结束页：644

文献类型：Review

关键词：Juvenile idiopathic arthritis; Macrophage; Macrophage activation syndrome; Monocyte; Single-cell RNA sequencing; Synoviocyte; T cell

摘要："Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children, with onset before age 16 and lasting for more than 6 weeks. JIA is a highly heterogeneous condition with various consequences for health and quality of life. For some JIA patients, early detection and intervention remain challenging. As a result, further investigation of the complex and unknown mechanisms underlying JIA is required. Advances in technology now allow us to describe the biological heterogeneity and function of individual cell populations in JIA. Through this review, we hope to provide novel ideas and potential targets for the diagnosis and treatment of JIA by summarizing the current findings of single-cell RNA sequencing studies and understanding how the major cell subsets drive JIA pathogenesis. & COPY; 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/)."

基金机构：National Key R amp;D Program of China [2021YFC2702003]

基金资助正文：<BOLD>Funding</BOLD> This work was supported by grants from the National Key R & D Program of China (No. 2021YFC2702003) . Acknowledgements Some of the figure icons are adapted from https:// www.figdraw.com /. Review criteria