Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

作者全名："Zhang, Hao; Yue, Xinghai; Chen, Zhe; Liu, Chao; Wu, Wantao; Zhang, Nan; Liu, Zaoqu; Yang, Liping; Jiang, Qing; Cheng, Quan; Luo, Peng; Liu, Guodong"

作者地址："[Zhang, Hao; Yue, Xinghai; Chen, Zhe; Luo, Peng; Liu, Guodong] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China; [Yue, Xinghai; Jiang, Qing] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing, Peoples R China; [Liu, Chao] Cent Hosp Zhuzhou, Dept Neurosurg, Zhuzhou, Peoples R China; [Wu, Wantao] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Peoples R China; [Zhang, Nan] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan, Peoples R China; [Liu, Zaoqu] Zhengzhou Univ, Dept Intervent Radiol, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Yang, Liping] Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing, Peoples R China; [Cheng, Quan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China; [Cheng, Quan] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China; [Luo, Peng] Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Peoples R China"

通信作者："Luo, P; Liu, GD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China.; Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China.; Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.; Luo, P (通讯作者)，Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Peoples R China."

来源：MOLECULAR CANCER

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001073695300001

JCR分区：Q1

影响因子：27.7

年份：2023

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：CAF; Clinical trial; Microenvironment; Immunotherapy; Target

摘要："Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment. The versatility and sophisticated mechanisms of CAFs in facilitating cancer progression have been elucidated extensively, including promoting cancer angiogenesis and metastasis, inducing drug resistance, reshaping the extracellular matrix, and developing an immunosuppressive microenvironment. Owing to their robust tumor-promoting function, CAFs are considered a promising target for oncotherapy. However, CAFs are a highly heterogeneous group of cells. Some subpopulations exert an inhibitory role in tumor growth, which implies that CAF-targeting approaches must be more precise and individualized. This review comprehensively summarize the origin, phenotypical, and functional heterogeneity of CAFs. More importantly, we underscore advances in strategies and clinical trials to target CAF in various cancers, and we also summarize progressions of CAF in cancer immunotherapy."

基金机构："National Natural Science Foundation of China [82073893]; Hunan Provincial Natural Science Foundation of China [2022JJ20095]; Hunan Provincial Health Committee Foundation of China [202204044869]; China Postdoctoral Science Foundation [2023MD734131]; Chongqing Postdoctoral Science Foundation [CSTB2023NSCQBHX0002]; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University, Chongqing Scientific and Health Joint Medical Research Project [2020GDRC021]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (NO. 82073893), Hunan Provincial Natural Science Foundation of China (NO.2022JJ20095), Hunan Provincial Health Committee Foundation of China (NO.202204044869), China Postdoctoral Science Foundation (2023MD734131), Chongqing Postdoctoral Science Foundation (CSTB2023NSCQBHX0002), Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University, Chongqing Scientific and Health Joint Medical Research Project (2020GDRC021)."