Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy

作者全名："Ye, Haixia; Li, Dongqian; Wei, Xia; Yu, Lehua; Jia, Lang"

作者地址："[Ye, Haixia; Li, Dongqian; Wei, Xia; Yu, Lehua; Jia, Lang] Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Chongqing 400010, Peoples R China; [Ye, Haixia] Chongqing City Management Coll, Dept Rehabil Teaching & Res, Chongqing 401331, Peoples R China"

通信作者："Yu, LH; Jia, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Chongqing 400010, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001074202900001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Mitophagy is critical for maintaining proper cellular functions, and it contributes to the onset and progression of osteoarthritis (OA). A recent study showed that focused low-intensity pulsed ultrasound (FLIPUS) could activate mitophagy, but the molecular mechanism remains unclear. This study aimed to elucidate the chondroprotective effects of FLIPUS in OA and the regulatory effects on FUN14-domain containing 1 (FUNDC1-mediated mitophagy. In vitro, FLIPUS improved inflammatory response, anabolism, and catabolism in interleukin (IL)-1 beta-induced OA chondrocytes. The chondroprotective effects of FLIPUS were attributed to promoting the expression of phosphoglycerate mutase 5 (PGAM5) and the dephosphorylation of FUNDC1 at serine 13 (Ser13), as well as promoting the mitophagy process. In vivo, FLIPUS reduced the cartilage degeneration and apoptosis and reversed the change of anabolic-and catabolic-related proteins in destabilized medial meniscus (DMM)-induced mouse model. Thus, the study indicates that FLIPUS exhibits a chondroprotective effect via activating impaired FUNDC1-mediated mitophagy."

基金机构：CQMU Program for Youth Innovation in Future Medicine [kryc-gg-2116]; Senior Medical Talents Program of Chongqing for Young and Middle-aged people [W0196]

基金资助正文："This research was funded by the National Natural Science Foundation of China (Grant No. 81802234) , the Natural Science Foundation of Chongqing (Grant Nos. cstc2020jcyj-msxmX0134, cstc2018jcyjAX0180) , the Traditional Chinese Medicine Science and Technology Project of Chongqing (Grant No. ZY201802104) , the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (kryc-gg-2116) , CQMU Program for Youth Innovation in Future Medicine (NO. W0196) , and Senior Medical Talents Program of Chongqing for Young and Middle-aged people.r (kryc-gg-2116) , CQMU Program for Youth Innovation in Future Medicine (NO. W0196) , and Senior Medical Talents Program of Chongqing for Young and Middle-aged people."