Palladium-based multifunctional nanoparticles for combined chemodynamic/photothermal and calcium overload therapy of tumors

作者全名："Zhang, Wenge; Li, Jiangyong; Chen, Lamei; Chen, Huan; Zhang, Liangke"

作者地址："[Zhang, Wenge; Li, Jiangyong; Chen, Lamei; Chen, Huan; Zhang, Liangke] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China"

通信作者："Zhang, LK (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China."

来源：COLLOIDS AND SURFACES B-BIOINTERFACES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001075532700001

JCR分区：Q1

影响因子：5.4

年份：2023

卷号：230

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Photothermal therapy; Chemodynamic therapy; Palladium nanoparticles; Calcium overload

摘要："Due to the high mortality and incidence rates associated with tumors and the specificity of the tumor microenvironment (TME), it is difficult to achieve a complete cure for tumors using a single therapy. In this study, calcium carbonate-modified palladium hydride nanoparticles (PdH@CaCO3) were prepared and utilized for the combined treatment of tumors through chemodynamic therapy (CDT)/photothermal therapy (PTT) and calcium overload therapy. After entering tumor cells, PdH@CaCO3 releases calcium ions (Ca2+) and PdH once it reaches the TME due to the pH reactivity of the calcium carbonate coating. The mitochondrial membrane potential is lowered by the Ca2+, leading to irreversible cell damage. Meanwhile, PdH reacts with excessive hydrogen peroxide (H2O2) in the TME via the Fenton reaction, generating hydroxyl radicals (.OH). Moreover, PdH is an excellent photothermal agent that can kill tumor cells under laser irradiation, leading to significant anti-tumor effects. In vitro and in vivo studies have demonstrated that PdH@CaCO3 could combine CDT/PTT and calcium overload therapy, exhibiting great clinical potential in the treatment of tumors."

基金机构：Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0795]; National Natural Science Foundation of China [81871368]

基金资助正文：This work was supported by the Natural Science Foundation Project of CQ CSTC (cstc2018jcyjAX0795) and the National Natural Science Foundation of China (81871368) .