Mechanistic insight into the adjuvant effect of co-exposure to ultrafine carbon black and high humidity on allergic asthma

作者全名："Deng, Rui; Li, Jia; Wu, Haiping; Wang, Mingpu"

作者地址："[Deng, Rui; Wang, Mingpu] Chongqing Univ, Sch Civil Engn, Joint Int Res Lab Green Bldg & Built Environm, Minist Educ, Chongqing 400045, Peoples R China; [Li, Jia] Chongqing Med Univ, Affiliated Hosp 1, Ctr Clin Mol Med Detect, Chongqing 400016, Peoples R China; [Wu, Haiping] Chongqing Med Univ, Coll Lab Med, Key Lab Clin Lab Diagnost, Minist Educ, Chongqing 400016, Peoples R China"

通信作者："Deng, R (通讯作者)，Chongqing Univ, Sch Civil Engn, Joint Int Res Lab Green Bldg & Built Environm, Minist Educ, Chongqing 400045, Peoples R China."

来源：ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:001075806400001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Allergic asthma; High humidity; Ultrafine particles; Combined exposure; Molecular mechanisms; Adjuvant effect

摘要："Respiratory diseases continue to be a major global concern, with allergies and asthma often discussed as critical areas of study. While the role of environmental risk factors, such as non-allergenic pollutants and high humidity, in asthma induction is often mentioned, there is still a lack of thorough research on their co-exposure. This study aims to investigate the adjuvant effect of ultrafine carbon black (30-50 nm) and high humidity (70% relative humidity) on the induction of allergic asthma. A mouse model of asthma was established using ovalbumin, and airway hyperresponsiveness, remodeling, and inflammation were measured as the endpoint effects of asthma. The mediating role of the oxidative stress pathway and the transient receptor potential vanilloid 1 pathway in asthma induction was validated using pathway inhibitors vitamin E and capsaicin, respectively. Co-exposure to ultrafine carbon black and high humidity had a significant impact on metabolic pathways in the lung, including aminoacyl-tRNA biosynthesis, glycerophospholipid metabolism, and ATP-binding cassette transporters. However, administering vitamin E and capsaicin altered the effects of co-exposure on the lung metabolome. These results offer new insights into the health risk assessment of co-exposure to environmental risk factors and provide an important reference point for the prevention and treatment of allergic asthma."

基金机构：This work was supported by the National Natural Science Foundation of China (42207486) and China Postdoctoral Science Foundation (2021M700580). [42207486]; National Natural Science Foundation of China [2021M700580]; China Postdoctoral Science Foundation

基金资助正文：This work was supported by the National Natural Science Foundation of China (42207486) and China Postdoctoral Science Foundation (2021M700580).