Tanshinone I attenuates gastric precancerous lesions by inhibiting epithelial mesenchymal transition through the p38/STAT3 pathway

作者全名："Liang, Dan; Tang, Shiyun; Liu, Lu; Zhao, Maoyuan; Ma, Xiao; Zhao, Yanling; Shen, Caifei; Liu, Qingsong; Tang, Jianyuan; Zeng, Jinhao; Chen, Nianzhi"

作者地址："[Liang, Dan; Tang, Shiyun; Zhao, Maoyuan] Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China; [Liu, Lu; Ma, Xiao] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu, Peoples R China; [Zhao, Yanling] Chinese Peoples Liberat Army Gen Hosp, Dept Pharm, Beijing, Peoples R China; [Shen, Caifei] Hosp Chengdu Univ Tradit Chinese Med, Dept Endoscopy Ctr, Chengdu, Peoples R China; [Liu, Qingsong; Zeng, Jinhao] Hosp Chengdu Univ Tradit Chinese Med, Dept Gastroenterol, Chengdu, Peoples R China; [Tang, Jianyuan] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China; [Chen, Nianzhi] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China"

通信作者："Zeng, JH (通讯作者)，Hosp Chengdu Univ Tradit Chinese Med, Dept Gastroenterol, Chengdu, Peoples R China.; Tang, JY (通讯作者)，Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.; Chen, NZ (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China."

来源：INTERNATIONAL IMMUNOPHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001077765600001

JCR分区：Q1

影响因子：4.8

年份：2023

卷号：124

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Gastric precancerous lesions; Epithelial-mesenchymal transition; Tanshinone I; p38/STAT3; Gastric cancer

摘要："Background: Gastric precancerous lesions (GPLs) are omens for gastric cancer (GC), which developing with a series of pathological changes of gastric mucosa. Reversing epithelial-mesenchymal transition (EMT) in gastric mucosa is the main approach to restrain GPLs from evolving into cancer. Tanshinone I (Tan-I), the active ingredients of traditional Chinese herb Salvia miltiorrhiza, has exhibited anticancer effect. Purpose: To investigate the effect and mechanism of Tan-I in intervening GPLs, and provide a new therapeutic strategy for prevention of GC. Methods: Gastric mucosal epithelial cells were treated with the N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) to construct MNNG-induced cell (MC cell) of gastric mucosa that undergoing EMT process. Then, this study explored the effect and mechanism of Tan-I in vitro. Subsequently, this study constructed GPL mice to clarify the exact efficacy and mechanism of Tan-I on GPLs. Results: Tan-I inhibited MC cell proliferation, invasion and migration. Simultaneously, the aberrant expression of E-cadherin and N-cadherin were reversed. Tan-I attenuated inflammation by reducing the release of nitric oxide, TNF alpha and IL-1 beta. Tan-I reversed the EMT and inflammatory processes by regulating p38 and STAT3. Conclusion: This study showed that Tan-I inhibited the progression of GPLs by reversing the EMT process and reducing inflammation by restraining the p38/STAT3 signaling pathway."

基金机构："National Natural Science Foundation of China [82174346, 82192915]; Central Govern-ment Guides Local Science and Technology Development Projects of Sichuan Provincial Science and Technology Department [2021ZYD0107]; Program of Science and Technology Department of Sichuan Province [2023NSFSC0039]; Xinglin Scholar Research Promotion Project of Chengdu University of TCM [QJRC2022008, QJJJ2022010]"

基金资助正文："<BOLD>Funding Information</BOLD> This work was supported by National Natural Science Foundation of China (Grant nos. 82174346 and 82192915) , and the Central Govern-ment Guides Local Science and Technology Development Projects of Sichuan Provincial Science and Technology Department (Grant no. 2021ZYD0107) , the Program of Science and Technology Department of Sichuan Province (Grant no. 2023NSFSC0039) , and the Xinglin Scholar Research Promotion Project of Chengdu University of TCM (Grant nos. QJRC2022008 and QJJJ2022010) ."