The prognostic and predictive value of plasma D-dimer in children with neuroblastoma: a 7-year retrospective analysis at a single institution

作者全名："Wang, Zhen-Ni; Zhang, Yao; Sun, Jian; Zhao, Zhen-Zhen; Wang, Shan; Yang, Chao"

作者地址："[Wang, Zhen-Ni; Zhang, Yao; Sun, Jian; Zhao, Zhen-Zhen; Wang, Shan; Yang, Chao] Chongqing Med Univ, Dept Pediat Surg Oncol, Childrens Hosp, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Wang, Zhen-Ni; Zhang, Yao; Sun, Jian; Zhao, Zhen-Zhen; Wang, Shan; Yang, Chao] Natl Int Sci & Technol Cooperat Base Crit Children, Chongqing, Peoples R China; [Wang, Zhen-Ni; Zhang, Yao; Sun, Jian; Zhao, Zhen-Zhen; Wang, Shan; Yang, Chao] Minist Educ, Chongqing Key Lab Pediat, Key Lab Child Dev Dis Res, Chongqing, Peoples R China"

通信作者："Yang, C (通讯作者)，Chongqing Med Univ, Dept Pediat Surg Oncol, Childrens Hosp, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：ANNALS OF SURGICAL TREATMENT AND RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001077828800002

JCR分区：Q3

影响因子：1.2

年份：2023

卷号：105

期号：3

开始页：148

结束页：156

文献类型：Article

关键词：Child; D-dimer; Neuroblastoma; Prognosis

摘要："Purpose: Elevated plasma D-dimer level is a poor prognostic factor for many solid tumors. However, limited research has been conducted on D-dimer in children with neuroblastoma (NB), and its clinical significance remains unclear. The present study investigated the clinical and prognostic significance of D-dimer in pediatric NB patients.Methods: A retrospective analysis of all newly admitted NB patients was conducted from January 2014 to December 2020. Baseline clinicopathological features, preoperative laboratory parameters, and follow-up information were collected. Univariate and multivariate analyses were performed to determine the relationship between D-dimer level, clinical features, and the prognostic value.Results: Among 266 patients, the median value of D-dimer was 2.98 ng/mL, of which 132 patients showed elevated D-dimer levels before surgery (>2.98 ng/mL). Univariate analysis revealed that elevated D-dimer was significantly associated with age, hemoglobin, neutrophil-to-lymphocyte ratio, neuron-specific enolase, 24-hour vanillylmandelic acid, overall survival, and so on (P < 0.05). Patients with elevated D-dimer levels had shorter median overall survival time when compared with normal D-dimer levels (P = 0.01). The prognosis was better in patients with normal D-dimer levels when combined with lower age, ganglioneuroblastoma tumor type, lower stage on International Neuroblastoma Staging System, low-risk group, and without bone metastasis or bone marrow metastasis. The continuous increase of D-dimer level after treatment indicated tumor recurrence or progression.Conclusion: A high D-dimer level is associated with low overall survival, and an elevated D-dimer level after treatment indicates tumor recurrence and progression. D-dimer can be used as one of the evaluation factors for NB treatment or prognosis."

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