"Uric acid is a biomarker for heart failure, but not therapeutic target: result from a comprehensive meta-analysis"

作者全名："Qin, Shiwei; Xiang, Meilin; Gao, Lei; Cheng, Xiaocheng; Zhang, Dongying"

作者地址："[Qin, Shiwei; Xiang, Meilin; Gao, Lei; Zhang, Dongying] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China; [Cheng, Xiaocheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Cheng, Xiaocheng; Zhang, Dongying] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, 1 Youyi St, Chongqing 400016, Peoples R China"

通信作者："Cheng, XC; Zhang, DY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, 1 Youyi St, Chongqing 400016, Peoples R China."

来源：ESC HEART FAILURE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001078205600001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Heart failure; Meta-analysis; Serum uric acid; Systematic review; Uric acid-lowering therapy

摘要："AimsThis systematic review and meta-analysis aimed to investigate the association between serum uric acid (SUA) levels and the incidence rate and prognosis of heart failure (HF), as well as the impact of uric acid-lowering treatment on HF patients.Methods and resultsPubMed and Embase were searched for original articles reporting on the association between SUA and HF incidence, adverse outcomes, and the effect of uric acid-lowering treatment in HF patients. Data were pooled using random effects or fixed effects models. Univariable meta-regression analysis assessed the influence of study characteristics on research outcomes. Statistical analyses were conducted using RevMan software and STATA software version 15.0. Eleven studies on HF incidence and 24 studies on adverse outcomes in HF patients were included. Higher SUA levels were associated with an increased risk of HF (RR: 1.81, 95% CI: 1.53-2.16), all-cause mortality (RR: 1.44, 95% CI: 1.25-1.66), cardiac death (RR: 1.56, 95% CI: 1.32-1.84), and HF rehospitalization (RR: 2.07, 95% CI: 1.37-3.13) in HF patients. Uric acid-lowering treatment was found to increase all-cause mortality in HF patients (RR: 1.15, 95% CI: 1.05-1.25).ConclusionsUric acid is an independent predictor of heart failure occurrence and adverse prognosis. Targeting uric acid lowering as a therapeutic intervention does not improve the prognosis of patients with heart failure. It may not be advisable to use traditional urate-lowering drugs in young patients with heart failure, and elderly patients should exercise caution when using them."

基金机构：We thank all the participants in the study.

基金资助正文：We thank all the participants in the study.