Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis

作者全名："Deng, Yueling; Jiang, Tao; Li, Jinhao; Yu, Pingping; Mei, Ying; Li, Maojun; Qi, Xiaoya; Liu, Fuyao"

作者地址："[Deng, Yueling; Jiang, Tao; Yu, Pingping; Mei, Ying; Qi, Xiaoya] Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China; [Li, Jinhao; Liu, Fuyao] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Liu, Fuyao] Univ Texas MD Anderson Canc Ctr, Dept GI Med Oncol, Houston, TX 77030 USA; [Li, Maojun] Linshui Cty People Hosp, Guangan, Sichuan, Peoples R China"

通信作者："Qi, XY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China.; Liu, FY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China.; Liu, FY (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept GI Med Oncol, Houston, TX 77030 USA."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001078229400001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Recently, the existence of ferroptosis has been confirmed in chronic pancreatitis. However, its role in acute pancreatitis (AP) process, especially in critical status, has not yet been mentioned. To verify this hypothesis, we included 873 AP patients (training set) and 1,188 NAFLD patients (internal validation set) selected from MIMIC-III (Medical Information Mark for Intensive Care) database and 218 AP patients (external validation set) in Linshui County People's Hospital ICU data. We analyzed the correlation between mortality and ferroptosis associating factors (such as serum iron, ALP, lactate, etc.) in them through regression analysis. In addition, to test the significance of these factors, the nomogram, AUC, and DCA analysis were applied. The results showed that serum iron, IBC, ALP, and lactate (p < 0.05) were independent factors for the mortality and prognosis of these patients. These correlations suggest ferroptosis and follow-up cell programmed death may own an important clinical interference significance among this population."

基金机构：National Natural Science Foundation of China [82173117]

基金资助正文：ACKNOWLEDGMENTS We sincerely thank Johnson et al. for the great effort in the construction of the MIMIC -III database and selfless sharing of their data. The pro- tocol was financially supported by the National Natural Science Foundation of China (grant no: 82173117) .