Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning

作者全名："Huang, Chenshen; Zhu, Fengshuo; Zhang, Hao; Wang, Ning; Huang, Qi"

作者地址："[Huang, Chenshen] Fujian Med Univ, Fujian Prov Hosp, Shengli Clin Med Coll, Dept Gastrointestinal Surg, Fuzhou, Peoples R China; [Huang, Chenshen; Huang, Qi] Tongji Univ, Tongji Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China; [Wang, Ning] Zhejiang Univ, Huzhou Cent Hosp, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp, Huzhou, Peoples R China; [Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China; [Zhu, Fengshuo] Shanghai Ninth Peoples Hosp, Coll Stomatol, Dept Oral Maxillofacial Head & Neck Oncol, Shanghai, Peoples R China; [Zhu, Fengshuo] Jiao Tong Univ, Sch Med, Natl Clin Res Ctr Oral Dis, Shanghai Key Lab Stomatol, Shanghai, Peoples R China; [Zhu, Fengshuo] Shanghai Res Inst Stomatol, Shanghai, Peoples R China"

通信作者："Huang, CS (通讯作者)，Fujian Med Univ, Fujian Prov Hosp, Shengli Clin Med Coll, Dept Gastrointestinal Surg, Fuzhou, Peoples R China.; Huang, CS; Huang, Q (通讯作者)，Tongji Univ, Tongji Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China.; Wang, N (通讯作者)，Zhejiang Univ, Huzhou Cent Hosp, Dept Hepatobiliary & Pancreat Surg, Affiliated Hosp, Huzhou, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001078696000001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：9

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and play a critical role as pharmacological targets. An improved understanding of GPCRs' involvement in tumor microenvironment may provide new perspectives for cancer therapy. This study used machine learning to classify head and neck squamous cell carcinoma (HNSCC) patients into two GPCR-based subtypes. Notably, these subtypes showed significant differences in prognosis, gene expression, and immune microenvironment, particularly CD8+ T cell infiltration. S1PR4 emerged as a key regulator distinguishing the subtypes, positively correlated with CD8+ T cell proportion and cytotoxicity in HNSCC. It was predominantly expressed in CX3CR(1+)CD(8+) T cells among T cells. Upregulation of S1PR4 enhanced T cell function during CAR-T cell therapy, suggesting its potential in cancer immunotherapy. These findings highlight S1PR4 as an immune modulator for favorable prognosis in HNSCC, and offer a potential GPCR-targeted therapeutic option for HNSCC treatment."

基金机构：　

基金资助正文：