Comparative evaluation of personalized 3D-printed scaffold-driven double-barrel fibula flap for the reconstruction of segmented mandibular defects

作者全名："Zheng, Lingling; Chen, Dan; Wang, Chao; Ai, Liya; Li, Yongfeng; Hu, Min; Aversa, Raffaella; Wang, Lizhen; Fan, Yubo"

作者地址："[Zheng, Lingling; Chen, Dan; Wang, Chao; Ai, Liya; Wang, Lizhen; Fan, Yubo] Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Sch Engn Med,Key Lab Biomech & Mechanobiol,Minist, 37 Xueyuan Rd, Beijing 100083, Peoples R China; [Wang, Chao] Chongqing Med Univ, Stomatol Hosp, 426 Songshi North Rd, Chongqing 401147, Peoples R China; [Wang, Chao] Chinese Acad Med Sci, Res Unit Virtual Body & Virtual Surg Technol, 2019RU004, Beijing, Peoples R China; [Li, Yongfeng; Hu, Min] First Med Ctr PLA Gen Hosp, Dept Stomatol, Beijing 100853, Peoples R China; [Aversa, Raffaella] Univ Campania, Polytech Sch Engn & Base Sci, I-81031 Aversa, CE, Italy"

通信作者："Wang, C; Fan, YB (通讯作者)，Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Biol Sci & Med Engn, Sch Engn Med,Key Lab Biomech & Mechanobiol,Minist, 37 Xueyuan Rd, Beijing 100083, Peoples R China."

来源：MATERIALS & DESIGN

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001079108800001

JCR分区：Q1

影响因子：7.6

年份：2023

卷号：234

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Large bone defects; Mandibular reconstruction; Double-barrel fibula flap; Porous scaffold; Bone regeneration

摘要："The challenge of reconstructing large mandibular bone defects with double-barrel fibula flap (DBFF) is limited by the availability of autogenous bone, which remains a significant issue in maxillofacial surgery. This study aims to compare the novel scaffold-driven double-barrel approach with the DBFF method, and investigate the biomechanical behavior of 3D-printed porous titanium scaffolds with varying design parameters. The mandibular reconstruction model underwent FEA in two surgery phases, under two experimental loads and two design parameters. The experimental scaffold design was categorized into 9 groups based on the porous diameters (DP = 4 mm, 5 mm, 6 mm) and strut diameters (DS = 0.4 mm,0.5 mm,0.6 mm). The results illustrated that the stress in fibula, cortical and trabecular bones for all groups were within the ranges of normal physiological levels. The porous scaffolds effectively transmit mechanical stimulation, resulting in bone graft materials achieving up to 99.9% strain, with low stiffness to avoid stress shielding. The study revealed that the design parameters of Group B and Group F were more conducive to meeting biomechanical demands and promoting bone regeneration. This study presents scientifically proven and effective clinical solution for restoring both function and aesthetics of mandibular defects, while also providing valuable insights for future design criteria in bone regeneration scaffolds."

基金机构："National Natural Science Foundation of China [12072055, 11872135, 12172034, U20A20390]; Natural Science Foundation of Beijing [L212063]; Fundamental Research Funds for the Central Universities; 111 Project [B13003]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-016]; ""Belt and Road"" Innovative Talent Exchange Program for Foreign Experts of the State Administration of Foreign Experts Affairs [DL2023177001L]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (Grant No. 12072055, 11872135, 12172034, U20A20390) , Natural Science Foundation of Beijing (Grant No.L212063) and the Fundamental Research Funds for the Central Universities, the 111 Project (No.B13003) , CAMS Innovation Fund for Medical Sciences (CIFMS) under Grant 2019-I2M-5-016, ""Belt and Road"" Innovative Talent Exchange Program for Foreign Experts of the State Administration of Foreign Experts Affairs (No.DL2023177001L)"