"Depression associated with dietary intake of flavonoids: An analysis of data from the National Health and Nutrition Examination Survey, 2007-2010"

作者全名："Gui, Jianxiong; Han, Ziyao; Ding, Ran; Yang, Xiaoyue; Yang, Jiaxin; Luo, Hanyu; Huang, Dishu; Wang, Lingman; Jiang, Li"

作者地址："[Gui, Jianxiong; Han, Ziyao; Ding, Ran; Yang, Xiaoyue; Yang, Jiaxin; Luo, Hanyu; Huang, Dishu; Wang, Lingman; Jiang, Li] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neurol,Minist Educ,Key Lab Child Dev & Disord, Chongqing 400014, Peoples R China; [Jiang, Li] Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China"

通信作者："Jiang, L (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China."

来源：JOURNAL OF PSYCHOSOMATIC RESEARCH

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001079930000001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：173

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Flavonoids; Dietary; Depression; NHANES; Mediation analysis

摘要："Background: Flavonoids may have a protective effect against depression. The purpose of this study was to examine whether flavonoid intake was associated with depression. Methods: This is an observational cross-sectional study. We evaluated a sample of 8183 adults from the National Health and Nutrition Examination Survey (NHANES), 2007-2010. The participants had an average age of 46.7 years, and 48.4% of them were male. Flavonoid intake was obtained through dietary recall interviews, and it included six subclasses: isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, and flavonols. Depression was identified using the Patient Health Questionnaire (PHQ-9). Logistic regression was utilized to evaluate the association between flavonoid intake and depression. Restricted cubic splines (RCS) were utilized to investigate nonlinear associations. Differences between subgroups were explored. Mediation analysis was used to explore confounding/mediating factors. These models were adjusted for age, sex, race/ethnicity, poverty status, education, smoking status, alcohol consumption, BMI, energy intake, physical activity, and chronic diseases. Results: There were 765 individuals with depression (PHQ-9 score >= 10) in the sample. After adjusting for covariates, flavanones, flavones, and total flavonoid intake were associated with a lower likelihood of depression (OR (95% CI): 0.73(0.64,0.84); 0.36(0.21,0.63); 0.86(0.74,0.99), respectively). A significant inverse correlation was observed between flavonoid consumption and the somatic symptom score of the PHQ-9. We observed a stronger association between flavonoids and depression in non-Hispanic white groups. The relationship between the total flavonoid intake and depression was explained to some extent by sleep duration (13.8%). Conclusions: Flavonoid intake was associated with lower odds of depression."

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