The complete reversal effect following angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and beta-blockers after the primary diagnosis of dilated cardiomyopathy

作者全名："Liu, Tao; Zhou, Ping; Jiang, Xin; Wang, Na; Shou, Jialing; Fang, Yuqiang"

作者地址："[Liu, Tao; Wang, Na; Shou, Jialing; Fang, Yuqiang] Army Med Univ, Chongqing Inst Cardiol, Daping Hosp, Dept Cardiol, Chongqing, Peoples R China; [Zhou, Ping] First Peoples Hosp Chongqing Liang Jiang New Area, Dept Cardiol, Chongqing 401121, Peoples R China; [Jiang, Xin] Peoples Hosp Chongqing Da Du Kou Area, Dept Cardiol, Chongqing, Peoples R China; [Fang, Yuqiang] Army Med Univ, Dept Cardiol, Chongqing Inst Cardiol, Daping Hosp, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China"

通信作者："Fang, YQ (通讯作者)，Army Med Univ, Dept Cardiol, Chongqing Inst Cardiol, Daping Hosp, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China."

来源：JOURNAL OF RESEARCH IN MEDICAL SCIENCES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001080511500005

JCR分区：Q2

影响因子：1.5

年份：2023

卷号：28

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Angiotensin receptor blockers; angiotensin-converting enzyme inhibitors; beta-blockers; dilated cardiomyopathy

摘要："Background: Whether combination administration of angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and beta-blockers (BBs) has a ""reversal"" effect on cardiac structure and function for first-diagnosed idiopathic dilated cardiomyopathy (FSIDCM) patients with unclear etiologies and inducements is unknown. Materials and Methods: We studied the effect of the protocol on FSIDCM patients. The effect was investigated in 26 FSIDCM patients. The criteria of ""complete reversal"" included left ventricular end-diastolic diameter (LVEDD)<= 50 mm for females or <= 55 mm for males and left ventricular ejection fraction (LVEF) >= 45%; the criteria of ""partial reversal"" was the decreased rate of LVEDD (Delta LVEDD) >10% or the increase rate of LVEF (Delta LVEF) >10%; the criteria of ""no reversal"" included LVEDD >50 mm for females or >55 mm for males and Delta LVEDD <10%, and LVEF <45% and Delta LVEF <10%. Results: Within the follow-up period, nine patients showed ""complete reversal,"" eight ""partial reversal,"" and nine ""no reversal."" Improvements in echocardiogram parameters were the most significant in ""complete reversal"" patients (P < 0.001), followed by ""partial reversal"" and ""no reversal"" patients (P < 0.05). The QRS (Q wave, R wave, S wave) duration and symptoms duration in ""complete reversal"" patients were the shortest, followed by ""partial reversal"" and ""no reversal"" patients. Conclusion: ACEIs or ARBs and BBs have a ""complete reversal"" effect on the left ventricular size and function of some FSIDCM patients. Patients with a narrow QRS and short symptom duration may have a good response."

基金机构：National Natural Science Foundation of China [81570312]

基金资助正文：This study was funded by National Natural Science Foundation of China (program no. 81570312)