"Rhubarb charcoal-crosslinked chitosan/silk fibroin sponge scaffold with efficient hemostasis, inflammation, and angiogenesis for promoting diabetic wound healing"

作者全名："Wang, Shang; Zhang, Yi; Shi, Yan; He, Qifeng; Tan, Qi; Peng, Ze; Liu, Yuzhe; Li, Dong; Li, Xuezhi; Ke, Dazhi; Wang, Jianwei"

作者地址："[Wang, Shang; Tan, Qi; Peng, Ze; Liu, Yuzhe; Li, Dong; Li, Xuezhi; Wang, Jianwei] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China; [Zhang, Yi; Ke, Dazhi] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400016, Peoples R China; [Shi, Yan] Nanchang Univ, Affiliated Hosp 1, Med Ctr Burn Plast & Wound Repair, Nanchang 330006, Jiangxi, Peoples R China; [He, Qifeng] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Li, Xuezhi; Wang, Jianwei] Chongqing Coll Tradit Chinese Med, Chongqing 402760, Peoples R China"

通信作者："Wang, JW (通讯作者)，Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.; Ke, DZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001080908900001

JCR分区：Q1

影响因子：7.7

年份：2023

卷号：253

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Rhubarb charcoal; Re-epithelization; Wound healing

摘要："Diabetic patients often experience long-term risks due to chronic inflammation and delayed re-epithelialization during impaired wound healing. Although the severity of this condition is well known, the treatment options for diabetic wounds are limited. Rhubarb charcoal, a well-known traditional Chinese medicine, has been used to treat skin wounds for thousands of years. We produced a chitosan/silk fibroin sponge scaffold loaded with natural carbonized rhubarb and crosslinked it by freeze-drying to create a highly efficient RCS/SF scaffold. Rhubarb carbon and carboxymethyl chitosan exhibit antibacterial activity and promote wound healing. Owing to its 3D porous structure, this scaffold is antibacterial and pro-angiogenic. It also possesses remarkable properties, such as excellent swelling and biocompatibility. The supportive effect of carbonized rhubarb on mouse fibroblast migration is mediated at the cellular/tissue level by increased skin neovascularization and re-epithelization. Compared to the control group, RCS/SF scaffolds promoted faster healing, increased neovascularization, enhanced collagen deposition, and re-epithelialization within two weeks. The scaffold's pro-healing properties and efficient release of carbonized rhubarb, with rapid hemostatic and good sterilization effects, make it an outstanding candidate for treating diabetic wounds and novel therapeutic interventions for diabetic ulcers."

基金机构：Talents Project of Chongqing [cstc2022ycjh-bgzxm0010]; Chongqing Traditional Chinese Medicine Inheritance and Innovation Team Project; Xinglin Program of Chongqing TCM/TCM-integrated Key Discipline [2021-ZDXK-DB01]

基金资助正文："This study was supported by the Talents Project of Chongqing (cstc2022ycjh-bgzxm0010) , Chongqing Traditional Chinese Medicine Inheritance and Innovation Team Project and the Xinglin Program of Chongqing TCM/TCM-integrated Key Discipline (Grant No.2021-ZDXK-DB01) ."