A "biomimetic bone-magnet" with suitable mechanical properties concurrently performs accurate target collection of nanoparticles for magnetothermally driven osteosarcoma thermo-chemotherapy
作者全名："Liang, Bing; Cao, Yijia; Wang, Xinmei; Zhou, Hang; Wang, Mengna; Cao, Youde; Lu, Weizhong; Yu, Kexiao"
作者地址："[Liang, Bing; Wang, Xinmei; Zhou, Hang; Wang, Mengna; Cao, Youde] Chongqing Med Univ, Coll Basic Med, Dept Pathol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Liang, Bing; Wang, Xinmei; Cao, Youde] Chongqing Med Univ, Mol Med Diagnost & Testing Ctr, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Liang, Bing; Wang, Xinmei; Cao, Youde] Chongqing Med Univ, Affiliated Hosp 1, Dept Pathol, 1 Youyi Rd, Chongqing 400042, Peoples R China; [Cao, Yijia] Chongqing Med Univ, Univ Town Hosp, Dept Gen Surg, Chongqing 401331, Peoples R China; [Lu, Weizhong; Yu, Kexiao] Chongqing Hosp Tradit Chinese Med, Dept Orthoped, 6 Panxi Seventh Branch Rd, Chongqing 400021, Peoples R China"
通信作者："Yu, KX (通讯作者)，Chongqing Hosp Tradit Chinese Med, Dept Orthoped, 6 Panxi Seventh Branch Rd, Chongqing 400021, Peoples R China."
来源：MATERIALS & DESIGN
ESI学科分类：MATERIALS SCIENCE
WOS号：WOS:001080918900001
JCR分区：Q1
影响因子：7.6
年份：2023
卷号：234
期号：
开始页：
结束页：
文献类型：Article
关键词：Biomimetic bone magnets; Osteosarcoma; Targeted therapy; Magnetothermal chemotherapy
摘要："Osteolytic lesions of bone tumors lead to stress-induced loss of load-bearing bones, making it difficult to treat tumors and repair bone tissue structures. Magnetic hyperthermia has become an effective minimally invasive treatment for malignant bone tumors without depth limitations. However, the effectiveness of magnetic heat therapy alone is not satisfactory, and if combined with chemotherapy, it can lead to significant systemic side effects. It is important to efficiently target chemotherapy substances to the correct area for combined therapy. We have developed a biomimetic bone magnet (BBM) that uses polymethyl methacrylate (PMMA) bone cement-loaded permanent magnet materials with good support performance to create an intrinsic tumor magnetic field. This magnetic field has magnetothermal properties and collects drug-loaded magnetic phase change nanoparticles (mCNPs) circulating in the blood for magnetothermally triggered chemotherapy. Moreover, PMMA has good mechanical properties, providing potential stress support for bone reconstruction after bone tumor treatment. Importantly, both in vivo and in vitro experimental results demonstrated the effectiveness of magnetic hyperthermia through minimally invasive injection of BBM phase transition. This new method achieves magnetic targeting by manufacturing tumor biomagnets to generate strong magnetic fields within the tumor, which opens up new avenues for treatment strategies for malignant bone tumors."
基金机构："National Natural Science Foundation of China [82203067, 82102909]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0447, CSTB2022NSCQ-MSX0109, CSTB2023NSCQ-MSX0185]; Scientific and Technology research program of Chongqing municipal education commission [KJQN202300458]; ""Light of West China"" Program; Chongqing High- level Talents Program for Young and Middleaged Medical Professionals by Dr. Yu, Joint Project of Chongqing Health Commission and Science and Technology Bureau [2022QNXM066]"
基金资助正文："We acknowledge financial support from the project of the National Natural Science Foundation of China (Grant Nos. 82203067 and 82102909) , the Natural Science Foundation of Chongqing (Grant Nos. cstc2020jcyj-msxmX0447, CSTB2022NSCQ-MSX0109 and CSTB2023NSCQ-MSX0185) , Scientific and Technology research program of Chongqing municipal education commission (Grant NO. KJQN202300458) , ""Light of West China"" Program and Chongqing High- level Talents Program for Young and Middleaged Medical Professionals by Dr. Yu, Joint Project of Chongqing Health Commission and Science and Technology Bureau (Grant NO. 2022QNXM066) ."
