Evaluation of the osteoconductivity and the degradation of novel hydroxyapatite/polyurethane combined with mesoporous silica microspheres in a rabbit osteomyelitis model

作者全名："Wang, Qi; Du, Jialei; Sun, Quanbo; Xiao, Shanwen; Huang, Wei"

作者地址："[Wang, Qi; Du, Jialei; Sun, Quanbo; Xiao, Shanwen] Heze Med Coll, Affiliated Hosp, Dept Orthoped, 777 Zhujiang Rd, Heze 274000, Shandong, Peoples R China; [Huang, Wei] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Chongqing, Peoples R China"

通信作者："Wang, Q (通讯作者)，Heze Med Coll, Affiliated Hosp, Dept Orthoped, 777 Zhujiang Rd, Heze 274000, Shandong, Peoples R China."

来源：JOURNAL OF ORTHOPAEDIC SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001082102100001

JCR分区：Q3

影响因子：1.3

年份：2023

卷号：31

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：bone defect; bone tissue engineering; hydroxyapatite; levofloxacin; polyurethane

摘要："Bone defects caused by osteomyelitis can lead to severe disability. Surgeons still face significant challenges in treating bone defects. Nano-hydroxyapatite (n-HA) plays an important role in bone tissue engineering due to its excellent biocompatibility and osteoconductivity. Levofloxacin (Levo) was encapsulated in mesoporous silica nanoparticles (MSNs) via electrostatic attraction to serve as a drug delivery system. MSNs were incorporated with n-HA and polyurethane (PU). The degradation and osteoconductivity properties of these novel composite scaffolds and their effectiveness in treating chronic osteomyelitis in a rabbit model were assessed. Gross pathology, radiographic imaging, micro-computed tomography, Van Gieson staining, and hematoxylin and eosin staining were conducted at 6 and 12 weeks. The group of composite scaffolds combining n-HA/PU with MSNs containing 5 mg Levo (n-HA/PU + Nano +5 mg Levo) composite scaffolds showed superior antibacterial properties compared to the other groups. At 12 weeks, the n-HA/PU + Nano +5 mg Levo composite scaffolds group exhibited significantly greater volume of new trabecular bone formation compared to the other three groups. The surface of the novel composite scaffolds exhibited degradation after 6 weeks implantation. The internal structure of the scaffolds collapsed noticeably after 12 weeks of implantation. The rate of material degradation corresponded to the rate of new bone ingrowth. This novel composite scaffold, which is biodegradable and osteoconductive, has potential as a drug delivery system for treating chronic osteomyelitis accompanied by bone defects."

基金机构：Development Program of the Affiliated Hospital of Heze Medical College [HYFY202108]; Medical and Health Science and Technology Development Plan Project of Shandong Province and Scientific Research [2019WS349]

基金资助正文："The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Development Program of the Affiliated Hospital of Heze Medical College (HYFY202108) and grant from the Medical and Health Science and Technology Development Plan Project of Shandong Province and Scientific Research (No: 2019WS349)."