A systematic review and<i> meta</i>-analysis of the efficacy of N95 respirators and surgical masks for protection against COVID-19

作者全名："Wu, Gaohong; Ji, Qingyang; Shi, Yuan"

作者地址："[Wu, Gaohong] Zhuhai Ctr Maternal & Child Hlth Care, Dept Neonatol, Zhuhai, Peoples R China; [Ji, Qingyang] Zhuhai Ctr Maternal & Child Hlth Care, Dept Breast Surg, Zhuhai, Peoples R China; [Wu, Gaohong; Shi, Yuan] Dept Neonatol Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat,Minist Educ ,Dept Neonato, Chongqing, Peoples R China"

通信作者："Shi, Y (通讯作者)，Dept Neonatol Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Chongqing Key Lab Pediat,Minist Educ ,Dept Neonato, Chongqing, Peoples R China."

来源：PREVENTIVE MEDICINE REPORTS

ESI学科分类：　

WOS号：WOS:001082290300001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：36

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：COVID-19; SARS-CoV-2; N95 respirators; Surgical masks; Meta -analysis

摘要："Former meta-analyses concluded that there was not sufficient evidence to determine the effect of surgical masks and N95 respirators. We collected randomized controlled trials (RCTs) and conducted a systematic review and meta-analysis to evaluate the efficacy of N95 respirators and surgical masks for protection against COVID-19. We retrieved relevant RCTs published between January 2019 and January 2023 by searching the PubMed, EMBASE, and Cochrane CENTRAL. Study quality was evaluated using the Cochrane Risk of Bias tool with the RevMan 5.4 software. Meta-analyses were conducted to calculate pooled estimates using the RevMan 5.4 software. A total of six RCTs were finally included. The findings revealed that wearing a mark made little difference in preventing COVID-19 [odds ratio (OR) = 0.10; 95% confidence interval (CI): 0.01-0.93; P = 0.04]. Subgroup analysis showed that the heterogeneity of data was I-2 = 64% (OR = 0.32; 95% CI: 0.06-1.77; P = 0.19) for surgical mask use and I-2 = 0% (OR = 0.03; 95 %CI: 0.01-0.15; P < 0.01) for N95 respirator use. The heterogeneity of data for medical staff was I-2 = 0% (OR = 0.03; 95 %CI: 0.01-0.12; P < 0.01). Meta-analysis indicated a protective effect of N95 respirators against COVID-19, particularly for medical staff. The use of surgical masks is not associated with a lower risk of COVID-19. However, the subgroup using N95 respirators, particularly medical staff, showed a significant protective. These findings suggest that N95 respirators should be reserved for high-risk medical staff in the absence of sufficient resources during an epidemic. But the number of included studies was small, mor-e studies in future analyses is required to reduce the risk of distribution bias."

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