Engineered Selenium/Human Serum Albumin Nanoparticles for Efficient Targeted Treatment of Parkinson's Disease via Oral Gavage

作者全名："Xu, Kai; Huang, Peng; Wu, Yixuan; Liu, Teng; Shao, Ningyi; Zhao, Lulu; Hu, Xiaoyan; Chang, Junlei; Peng, Yongbo; Qu, Shaogang"

作者地址："[Xu, Kai; Huang, Peng; Wu, Yixuan; Qu, Shaogang] Southern Med Univ, Nanfang Hosp, Dept Neurol, Guangzhou 510515, Guangdong, Peoples R China; [Xu, Kai; Huang, Peng; Wu, Yixuan; Qu, Shaogang] Guangdong Hong Kong Macao Greater Bay Area Ctr Br, Guangzhou 510515, Guangdong, Peoples R China; [Xu, Kai; Huang, Peng; Wu, Yixuan; Qu, Shaogang] Southern Med Univ, Key Lab Mental Hlth, Minist Educ, Guangzhou 510515, Guangdong, Peoples R China; [Liu, Teng] Cent South Univ, Dept Neonatol & Pediat, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China; [Shao, Ningyi] Univ Macau, Canc Ctr, Fac Hlth Sci, Taipa 999078, Macau, Peoples R China; [Zhao, Lulu; Peng, Yongbo] Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China; [Hu, Xiaoyan; Chang, Junlei] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomedicine & Biotechnol, Shenzhen Key Lab Biomimet Mat & Cellular Immunomo, Shenzhen 518055, Guangdong, Peoples R China; [Hu, Xiaoyan] Univ Chinese Acad Sci, Beijing 100864, Peoples R China; [Qu, Shaogang] Ganzhou Peoples Hosp, Dept Neurol, Ganzhou 341000, Jiangxi, Peoples R China"

通信作者："Qu, SG (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Neurol, Guangzhou 510515, Guangdong, Peoples R China.; Qu, SG (通讯作者)，Guangdong Hong Kong Macao Greater Bay Area Ctr Br, Guangzhou 510515, Guangdong, Peoples R China.; Qu, SG (通讯作者)，Southern Med Univ, Key Lab Mental Hlth, Minist Educ, Guangzhou 510515, Guangdong, Peoples R China.; Peng, YB (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China.; Qu, SG (通讯作者)，Ganzhou Peoples Hosp, Dept Neurol, Ganzhou 341000, Jiangxi, Peoples R China."

来源：ACS NANO

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001082655100001

JCR分区：Q1

影响因子：15.8

年份：2023

卷号：17

期号：20

开始页：19961

结束页：19980

文献类型：Article

关键词：Parkinson'sdisease; human serum albumin; selenium; nanosystem; treatment

摘要："Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopamine (DA) neurons in the midbrain substantia nigra pars compacta (SNpc). While existing therapeutic strategies can alleviate PD symptoms, they cannot inhibit DA neuron loss. Herein, a tailor-made human serum albumin (HSA)-based selenium nanosystem (HSA/Se nanoparticles, HSA/Se NPs) to treat PD that can overcome the intestinal epithelial barrier (IEB) and blood-brain barrier (BBB) is described. HSA, a transporter for drug delivery, has superior biological characteristics that make it an ideal potential drug delivery substance. Findings reveal that HSA/Se NPs have lower toxicity and higher efficacy than other selenium species and the ability to overcome the IEB and BBB to enrich DA neurons, which then protect MN9D cells from MPP+-induced neurotoxicity and ameliorate both behavioral deficits and DA neuronal death in MPTP-model mice. Thus, a therapeutic drug delivery system composed of orally gavaged HSA/Se NPs for the treatment of PD is described."

基金机构："Jiangxi Provincial Natural Science Foundation [20232ACB206021]; National Natural Science Foundation of China [81870991, U1603281]; Natural Science Foundation of Guangdong Province [2022A1515010352]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0857]"

基金资助正文："This work was supported by grants from Jiangxi Provincial Natural Science Foundation (No. 20232ACB206021 to Shaogang Qu), the National Natural Science Foundation of China (Grant Nos. 81870991 and U1603281 to Shaogang Qu), the Natural Science Foundation of Guangdong Province (Grant No. 2022A1515010352 to Shaogang Qu) and the Natural Science Foundation of Chongqing (Grant No. CSTB2022NSCQ-MSX0857 to Yongbo Peng)."