Influence of gut microbiota on resilience and its possible mechanisms

作者全名："Wang, Jianhui; Zhou, Ting; Liu, Feng; Huang, Yan; Xiao, Zhiyong; Qian, Yan; Zhou, Wenxia"

作者地址："[Wang, Jianhui; Liu, Feng; Huang, Yan; Xiao, Zhiyong; Zhou, Wenxia] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China; [Wang, Jianhui; Liu, Feng; Huang, Yan; Xiao, Zhiyong; Zhou, Wenxia] State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China; [Zhou, Ting; Qian, Yan] Chongqing Med Univ, Dept Pharm, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Zhou, WX (通讯作者)，Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China.; Zhou, WX (通讯作者)，State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China.; Qian, Y (通讯作者)，Chongqing Med Univ, Dept Pharm, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001083804400009

JCR分区：Q1

影响因子：8.2

年份：2023

卷号：19

期号：8

开始页：2588

结束页：2598

文献类型：Review

关键词：resilience; brain circuits; blood-brain barrier; immune system; epigenetics; gut microbiota

摘要："Excessive stress leads to disruptions of the central nervous system. Individuals' responses to stress and trauma differ from person to person. Some may develop various neuropsychiatric disorders, such as post-traumatic stress disorder, major depression, and anxiety disorders, while others may successfully adapt to the same stressful events. These two neural phenotypes are called susceptibility and resilience. Previous studies have suggested resilience/susceptibility as a complex, non-specific systemic response involving central and peripheral systems. Emerging research of mechanisms underlying resilience is mostly focussing on the physiological adaptation of specific brain circuits, neurovascular impairment of the blood-brain barrier, the role of innate and adaptive factors of the immune system, and the dysbiosis of gut microbiota. In accordance with the microbiota-gut-brain axis hypothesis, the gut microbiome directly influences the interface between the brain and the periphery to affect neuronal function. This review explored several up-to-date studies on the role of gut microbiota implicated in stressful events-related resilience/susceptibility. We mainly focus on the changes in behavior and neuroimaging characteristics, involved brain regions and circuits, the blood-brain barrier, the immune system, and epigenetic modifications, which contribute to stress-induced resilience and susceptibility. The perspective of the gut-brain axis could help to understand the mechanisms underlying resilience and the discovery of biomarkers may lead to new research directions and therapeutic interventions for stress-induced neuropsychiatric disorders."

基金机构：National Natural Science Foundation of China [82174006]; Beijing Municipal Natural Science Foundation [7222292]

基金资助正文：This review was supported by the National Natural Science Foundation of China (82174006) and the Beijing Municipal Natural Science Foundation (7222292).