Multi-omics reveal neuroprotection of <i>Acer truncatum Bunge</i> Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

作者全名："Chen, Xianyang; Song, Yige; Song, Wangting; Han, Jiarui; Cao, Hongli; Xu, Xiao; Li, Shujia; Fu, Yanmin; Ding, Chunguang; Lin, Feng; Shi, Yuan; Li, Jiujun"

作者地址："[Chen, Xianyang; Song, Yige; Song, Wangting; Han, Jiarui] Bao Feng Key Lab Genet & Metab, Beijing, Peoples R China; [Cao, Hongli] Capital Med Univ, Beijing Rehabil Hosp, Dept Resp, Beijing, Peoples R China; [Xu, Xiao; Li, Shujia; Fu, Yanmin; Li, Jiujun] China Med Univ, Shengjing Hosp, Plateau Med Res Ctr, Dept Pediat, Shenyang, Peoples R China; [Ding, Chunguang] Natl Ctr Occupat Safety & Hlth, Beijing, Peoples R China; [Lin, Feng] Fujian Med Univ, Sanming Hosp 1, Dept Neurol, Sanming, Fujian, Peoples R China; [Shi, Yuan] Chongqing Med Univ, Childrens Hosp Affiliated, Dept Neonatol, Chongqing, Peoples R China"

通信作者："Li, JJ (通讯作者)，China Med Univ, Shengjing Hosp, Plateau Med Res Ctr, Dept Pediat, Shenyang, Peoples R China."

来源：COMMUNICATIONS BIOLOGY

ESI学科分类：　

WOS号：WOS:001083931000004

JCR分区：Q1

影响因子：5.2

年份：2023

卷号：6

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. Acer truncatum Bunge Seed extract (ASO) is reported to have effect on cognitive improvement, but its molecular mechanisms on HIE are unclear. In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude. Transcriptomics and WGCNA analysis showed genes associated with lipid biosynthesis, redox homeostasis, neuronal growth, and synaptic plasticity regulated in the ASO group. Targeted and untargeted-lipidomics revealed decreased free fatty acids and increased phospholipids with favorable omega-3/omega-6/omega-9 fatty acid ratios, as well as reduced oxidized glycerophospholipids (OxGPs) in the ASO group. Combining multi-omics analysis demonstrated FA to FA-CoA, phospholipids metabolism, and lipid peroxidation were regulated by ASO treatment. Our results illuminated preliminary metabolism mechanism of ASO ingesting in rats, implying ASO administration as potential intervention strategy for HIE under high-altitude."

基金机构："This study was funded by Shengjing Hospital of China Medical University through project NO. 112-3110119086. We especially thank the instrumentation support from the Department of Pediatrics, Shengjing Hospital of China Medical University. [112-3110119086]; Shengjing Hospital of China Medical University; Department of Pediatrics, Shengjing Hospital of China Medical University"

基金资助正文："This study was funded by Shengjing Hospital of China Medical University through project NO. 112-3110119086. We especially thank the instrumentation support from the Department of Pediatrics, Shengjing Hospital of China Medical University."