Association between Residential Greenness and Human Microbiota: Evidence from Multiple Countries

作者全名："Zhang, Yi-Dan; Fan, Shu-Jun; Zhang, Zheng; Li, Jia-Xin; Liu, Xiao-Xuan; Hu, Li-Xin; Knibbs, Luke D.; Dadvand, Payam; Jalaludin, Bin; Browning, Matthew H. E. M.; Zhao, Tianyu; Heinrich, Joachim; He, Zhini; Chen, Cheng-Zhi; Zhou, Yuanzhong; Dong, Guang-Hui; Yang, Bo-Yi"

作者地址："[Zhang, Yi-Dan; Li, Jia-Xin; Liu, Xiao-Xuan; Jalaludin, Bin; Browning, Matthew H. E. M.; Zhao, Tianyu; Heinrich, Joachim; He, Zhini; Chen, Cheng-Zhi; Dong, Guang-Hui; Yang, Bo-Yi] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China; [Fan, Shu-Jun; Zhao, Tianyu; Zhou, Yuanzhong] Guangzhou Ctr Dis Control & Prevent, Dept Environm Hlth, Guangzhou 510440, Peoples R China; [Fan, Shu-Jun; Zhao, Tianyu] Guangzhou Med Univ, Inst Publ Hlth, Guangzhou Ctr Dis Control & Prevent, Guangzhou 510120, Guangdong, Peoples R China; [Zhang, Zheng; Zhao, Tianyu] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Cent Lab, Beijing, Peoples R China; [Hu, Li-Xin; Zhao, Tianyu] Sun Yat Sen Univ, Sch Publ Hlth, Dept Maternal & Child Hlth, Guangzhou, Peoples R China; [Knibbs, Luke D.; Heinrich, Joachim] Univ Sydney, Sch Publ Hlth, Camperdown, NSW, Australia; [Dadvand, Payam; Heinrich, Joachim] ISGlobal, Barcelona, Spain; [Dadvand, Payam] Univ Pompeu Fabra, Barcelona, Spain; [Dadvand, Payam] CIBER Epidemiol & Salud Publ, Madrid, Spain; [Jalaludin, Bin] Univ New South Wales, Sch Populat Hlth, Kensington, NSW, Australia; [Browning, Matthew H. E. M.] Clemson Univ, Dept Pk Recreat & Tourism Management, Clemson, SC 29634 USA; [Zhao, Tianyu] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Munich, Germany; [Zhao, Tianyu] Munich Univ Munich LMU, Comprehens Pneumol Ctr, Thorac Oncol Ctr, Munich, Germany; [Zhao, Tianyu] Justus Liebig Univ, German Ctr Lung Res, Giessen, Germany; [Zhao, Tianyu] Helmholtz Zent Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany; [Heinrich, Joachim] Univ Hosp LMU Munich, Inst & Clin Occupat Social & Environm Med, Munich, Germany; [Heinrich, Joachim] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia; [He, Zhini] Southern Med Univ, Food Safety & Hlth Res Ctr, Sch Publ Hlth, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Peoples R China; [Chen, Cheng-Zhi] Chongqing Med Univ, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Zhou, Yuanzhong] Zunyi Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Zunyi 563000, Peoples R China; [Yang, Bo-Yi] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China; [Dong, Guang-Hui] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China"

通信作者："Dong, GH; Yang, BY (通讯作者)，Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou, Peoples R China.; Yang, BY (通讯作者)，Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.; Dong, GH (通讯作者)，Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China."

来源：ENVIRONMENTAL HEALTH PERSPECTIVES

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:001084031400033

JCR分区：Q1

影响因子：10.1

年份：2023

卷号：131

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："BACKGROUND: Greenness, referring to a measurement of the density of vegetated land (e.g., gardens, parks, grasslands), has been linked with many human health outcomes. However, the evidence on greenness exposure and human microbiota remains limited, inconclusive, drawn from specific regions, and based on only modest sample size.OBJECTIVES: We aimed to study the association between greenness exposure and human microbial diversity and composition in a large sample across 34 countries and regions.METHODS: We explored associations between residential greenness and human microbial alpha-diversity, composition, and genus abundance using data from 34 countries. Greenness exposure was assessed using the normalized difference vegetation index and the enhanced vegetation index mean values in the month before sampling. We used linear regression models to estimate the association between greenness and microbial alpha-diversity and tested the effect modification of age, sex, climate zone, and pet ownership of participants. Differences in microbial composition were tested by permutational multivariate analysis of variance based on Bray-Curtis distance and differential taxa were detected using the DESeq2 R package between two greenness exposure groups split by median values of greenness.RESULTS: We found that higher greenness was significantly associated with greater richness levels in the palm and gut microbiota but decreased even-ness in the gut microbiota. Pet ownership and climate zone modified some associations between greenness and alpha-diversity. Palm and gut micro-bial composition at the genus level also varied by greenness. Higher abundances of the genera Lactobacillus and Bifidobacterium, and lower abundances of the genera Anaerotruncus and Streptococcus, were observed in people with higher greenness levels.DISCUSSION: These findings suggest that residential greenness was associated with microbial richness and composition in the human skin and gut sam-ples, collected across different geographic contexts. Future studies may validate the observed associations and determine whether they correspond to improvements in human health. https://doi.org/10.1289/EHP12186"

基金机构："National Key Research and Development Program of China [2018YFC1004300, 2018YFC1004301]; National Natural Science Foundation of China [81972992, 81872582, 81803196]"

基金资助正文："<B>Acknowledgments</B> This study was founded by the National Key Research and Development Program of China (2018YFC1004300 and 2018YFC1004301, both to B.-Y.Y.) , and the National Natural Science Foundation of China (81972992, to B.-Y.Y.; 81872582, to G.-H.D.; 81803196, to S.J.F.) . The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. The data that supported the findings of this study are available from B.-Y.Y. upon reasonable request."