Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

作者全名："Tobias, Deirdre K.; Merino, Jordi; Ahmad, Abrar; Aiken, Catherine; Benham, Jamie L.; Bodhini, Dhanasekaran; Clark, Amy L.; Colclough, Kevin; Corcoy, Rosa; Cromer, Sara J.; Duan, Daisy; Felton, Jamie L.; Francis, Ellen C.; Gillard, Pieter; Gingras, Veronique; Gaillard, Romy; Haider, Eram; Hughes, Alice; Ikle, Jennifer M.; Jacobsen, Laura M.; Kahkoska, Anna R.; Kettunen, Jarno L. T.; Kreienkamp, Raymond J.; Lim, Lee-Ling; Mannisto, Jonna M. E.; Massey, Robert; Mclennan, Niamh-Maire; Miller, Rachel G.; Morieri, Mario Luca; Most, Jasper; Naylor, Rochelle N.; Ozkan, Bige; Patel, Kashyap Amratlal; Pilla, Scott J.; Prystupa, Katsiaryna; Raghavan, Sridharan; Rooney, Mary R.; Schoen, Martin; Semnani-Azad, Zhila; Sevilla-Gonzalez, Magdalena; Svalastoga, Pernille; Takele, Wubet Worku; Tam, Claudia Ha-ting; Thuesen, Anne Cathrine B.; Tosur, Mustafa; Wallace, Amelia S.; Wang, Caroline C.; Wong, Jessie J.; Yamamoto, Jennifer M.; Young, Katherine; Amouyal, Chloe; Andersen, Mette K.; Bonham, Maxine P.; Chen, Mingling; Cheng, Feifei; Chikowore, Tinashe; Chivers, Sian C.; Clemmensen, Christoffer; Dabelea, Dana; Dawed, Adem Y.; Deutsch, Aaron J.; Dickens, Laura T.; DiMeglio, Linda A.; Dudenhoffer-Pfeifer, Monika; Evans-Molina, Carmella; Fernandez-Balsells, Maria Merce; Fitipaldi, Hugo; Fitzpatrick, Stephanie L.; Gitelman, Stephen E.; Goodarzi, Mark O.; Grieger, Jessica A.; Guasch-Ferre, Marta; Habibi, Nahal; Hansen, Torben; Huang, Chuiguo; Harris-Kawano, Arianna; Ismail, Heba M.; Hoag, Benjamin; Johnson, Randi K.; Jones, Angus G.; Koivula, Robert W.; Leong, Aaron; Leung, Gloria K. W.; Libman, Ingrid M.; Liu, Kai; Long, S. Alice; Lowe, William L., Jr.; Morton, Robert W.; Motala, Ayesha A.; Onengut-Gumuscu, Suna; Pankow, James S.; Pathirana, Maleesa; Pazmino, Sofia; Perez, Dianna; Petrie, John R.; Powe, Camille E.; Quinteros, Alejandra; Jain, Rashmi; Ray, Debashree; Ried-Larsen, Mathias; Saeed, Zeb; Santhakumar, Vanessa; Kanbour, Sarah; Sarkar, Sudipa; Monaco, Gabriela S. F.; Scholtens, Denise M.; Selvin, Elizabeth; Sheu, Wayne Huey-Herng; Speake, Cate; Stanislawski, Maggie A.; Steenackers, Nele; Steck, Andrea K.; Stefan, Norbert; Stoy, Julie; Taylor, Rachael; Tye, Sok Cin; Ukke, Gebresilasea Gendisha; Urazbayeva, Marzhan; Van der Schueren, Bart; Vatier, Camille; Wentworth, John M.; Hannah, Wesley; White, Sara L.; Yu, Gechang; Zhang, Yingchai; Zhou, Shao J.; Beltrand, Jacques; Polak, Michel; Aukrust, Ingvild; de Franco, Elisa; Flanagan, Sarah E.; Maloney, Kristin A.; McGovern, Andrew; Molnes, Janne; Nakabuye, Mariam; Njolstad, Pal Rasmus; Pomares-Millan, Hugo; Provenzano, Michele; Saint-Martin, Cecile; Zhang, Cuilin; Zhu, Yeyi; Auh, Sungyoung; de Souza, Russell; Fawcett, Andrea J.; Gruber, Chandra; Mekonnen, Eskedar Getie; Mixter, Emily; Sherifali, Diana; Eckel, Robert H.; Nolan, John J.; Philipson, Louis H.; Brown, Rebecca J.; Billings, Liana K.; Boyle, Kristen; Costacou, Tina; Dennis, John M.; Florez, Jose C.; Gloyn, Anna L.; Gomez, Maria F.; Gottlieb, Peter A.; Greeley, Siri Atma W.; Griffin, Kurt; Hattersley, Andrew T.; Hirsch, Irl B.; Hivert, Marie-France; Hood, Korey K.; Josefson, Jami L.; Kwak, Soo Heon; Laffel, Lori M.; Lim, Siew S.; Loos, Ruth J. F.; Ma, Ronald C. W.; Mathieu, Chantal; Mathioudakis, Nestoras; Meigs, James B.; Misra, Shivani; Mohan, Viswanathan; Murphy, Rinki; Oram, Richard; Owen, Katharine R.; Ozanne, Susan E.; Pearson, Ewan R.; Perng, Wei; Pollin, Toni I.; Pop-Busui, Rodica; Pratley, Richard E.; Redman, Leanne M.; Redondo, Maria J.; Reynolds, Rebecca M.; Semple, Robert K.; Sherr, Jennifer L.; Sims, Emily K.; Sweeting, Arianne; Tuomi, Tiinamaija; Udler, Miriam S.; Vesco, Kimberly K.; Vilsboll, Tina; Wagner, Robert; Rich, Stephen S.; Franks, Paul W."

作者地址："[Tobias, Deirdre K.; Santhakumar, Vanessa] Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA; [Tobias, Deirdre K.; Powe, Camille E.; Santhakumar, Vanessa] Harvard Med Sch, Boston, MA 02115 USA; [Tobias, Deirdre K.; Semnani-Azad, Zhila; Guasch-Ferre, Marta; Franks, Paul W.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA; [Merino, Jordi; Thuesen, Anne Cathrine B.; Andersen, Mette K.; Clemmensen, Christoffer; Hansen, Torben; Nakabuye, Mariam; Loos, Ruth J. F.] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark; [Merino, Jordi; Cromer, Sara J.; Kreienkamp, Raymond J.; Leong, Aaron; Powe, Camille E.; Florez, Jose C.; Hivert, Marie-France; Udler, Miriam S.] Massachusetts Gen Hosp, Div Endocrine, Diabet Unit, Boston, MA USA; [Merino, Jordi; Kreienkamp, Raymond J.; Deutsch, Aaron J.; Florez, Jose C.; Udler, Miriam S.] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA; [Ahmad, Abrar; Dudenhoffer-Pfeifer, Monika; Fitipaldi, Hugo; Pomares-Millan, Hugo; Gomez, Maria F.; Franks, Paul W.] Lund Univ, Diabet Ctr, Dept Clin Sci, Malmo, Sweden; [Aiken, Catherine] Rosie Hosp, Dept Obstet & Gynaecol, Cambridge, England; [Aiken, Catherine] Univ Cambridge, NIHR Cambridge Biomed Res Ctr, Cambridge, England; [Benham, Jamie L.] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada; [Benham, Jamie L.] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada; [Bodhini, Dhanasekaran] Madras Diabet Res Fdn, Dept Mol Genet, Chennai, Tamil Nadu, India; [Clark, Amy L.] St Louis Univ, SSM Hlth Cardinal Glennon Childrens Hosp, Dept Pediat, Div Pediat Endocrinol,Sch Med, St Louis, MO USA; [Colclough, Kevin; Hughes, Alice; Patel, Kashyap Amratlal; Young, Katherine; Jones, Angus G.; de Franco, Elisa; Flanagan, Sarah E.; McGovern, Andrew; Dennis, John M.; Hattersley, Andrew T.; Oram, Richard] Univ Exeter, Dept Clin & Biomed Sci, Sch Med, Exeter, Devon, England; [Corcoy, Rosa] ISCIII, CIBER BBN, Madrid, Spain; [Corcoy, Rosa] Inst Invest Biomed St Pau, Barcelona, Spain; [Corcoy, Rosa] Univ Autonoma Barcelona, Dept Med, Bellaterra, Spain; [Cromer, Sara J.; Kreienkamp, Raymond J.; Sevilla-Gonzalez, Magdalena; Deutsch, Aaron J.; Powe, Camille E.; Florez, Jose C.; Udler, Miriam S.] Broad Inst, Program Metab, Cambridge, MA USA; [Cromer, Sara J.; Kreienkamp, Raymond J.; Sevilla-Gonzalez, Magdalena; Deutsch, Aaron J.; Powe, Camille E.; Florez, Jose C.; Udler, Miriam S.] Broad Inst, Program Med & Populat Genet, Cambridge, MA USA; [Cromer, Sara J.; Sevilla-Gonzalez, Magdalena; Chikowore, Tinashe; Deutsch, Aaron J.; Leong, Aaron; Powe, Camille E.; Florez, Jose C.; Meigs, James B.; Udler, Miriam S.] Harvard Med Sch, Dept Med, Boston, MA USA; [Duan, Daisy] Johns Hopkins Univ, Div Endocrinol Diabet & Metab, Sch Med, Baltimore, MD USA; [Felton, Jamie L.; DiMeglio, Linda A.; Evans-Molina, Carmella; Harris-Kawano, Arianna; Ismail, Heba M.; Perez, Dianna; Monaco, Gabriela S. F.; Sims, Emily K.] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN USA; [Felton, Jamie L.; DiMeglio, Linda A.; Evans-Molina, Carmella; Harris-Kawano, Arianna; Ismail, Heba M.; Perez, Dianna; Monaco, Gabriela S. F.; Sims, Emily K.] Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, Indianapolis, IN USA; [Felton, Jamie L.; DiMeglio, Linda A.; Evans-Molina, Carmella; Harris-Kawano, Arianna; Ismail, Heba M.; Perez, Dianna; Monaco, Gabriela S. F.; Sims, Emily K.] Indiana Univ Sch Med, Ctr Diabet & Metab Dis, Indianapolis, IN USA; [Francis, Ellen C.] Rutgers Sch Publ Hlth, Dept Biostat & Epidemiol, Piscataway, NJ USA; [Gillard, Pieter; Mathieu, Chantal] Univ Hosp Leuven, Leuven, Belgium; [Gingras, Veronique] Univ Montreal, Dept Nutr, Montreal, PQ, Canada; [Gingras, Veronique] St Justine Univ Hosp Ctr, Res Ctr, Montreal, PQ, Canada; [Gaillard, Romy] Erasmus MC, Dept Pediat, Rotterdam, Netherlands; [Haider, Eram; Massey, Robert; Dawed, Adem Y.; Pearson, Ewan R.] Univ Dundee, Sch Med, Div Populat Hlth & Genom, Dundee, Scotland; [Ikle, Jennifer M.; Gloyn, Anna L.] Stanford Univ, Dept Pediat, Stanford Sch Med, Stanford, CA USA; [Ikle, Jennifer M.; Gloyn, Anna L.] Stanford Univ, Stanford Diabet Res Ctr, Stanford Sch Med, Stanford, CA USA; [Jacobsen, Laura M.] Univ Florida, Gainesville, FL USA; [Kahkoska, Anna R.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA; [Kettunen, Jarno L. T.; Tuomi, Tiinamaija] Helsinki Univ Hosp, Abdominal Ctr Endocrinol, Helsinki, Finland; [Kettunen, Jarno L. T.; Tuomi, Tiinamaija] Folkhalsan Res Ctr, Helsinki, Finland; [Kettunen, Jarno L. T.; Tuomi, Tiinamaija] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland; [Kreienkamp, Raymond J.] Boston Childrens Hosp, Dept Pediat, Div Endocrinol, Boston, MA USA; [Lim, Lee-Ling] Univ Malaya, Dept Med, Fac Med, Kuala Lumpur, Malaysia; [Lim, Lee-Ling] Asia Diabet Fdn, Hong Kong, Peoples R China; [Lim, Lee-Ling; Tam, Claudia Ha-ting; Huang, Chuiguo; Yu, Gechang; Zhang, Yingchai; Ma, Ronald C. W.] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China; [Mannisto, Jonna M. E.] Kuopio Univ Hosp, Dept Pediat, Kuopio, Finland; [Mannisto, Jonna M. E.] Kuopio Univ Hosp, Dept Clin Genet, Kuopio, Finland; [Mannisto, Jonna M. E.] Univ Eastern Finland, Dept Med, Kuopio, Finland; [Mclennan, Niamh-Maire; Reynolds, Rebecca M.; Semple, Robert K.] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland; [Miller, Rachel G.; Costacou, Tina] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA USA; [Morieri, Mario Luca] Univ Hosp Padova, Metab Dis Unit, Padua, Italy; [Morieri, Mario Luca] Univ Padua, Dept Med, Padua, Italy; [Most, Jasper] Zuyderland Med Ctr, Dept Orthoped, Sittard Geleen, Netherlands; [Naylor, Rochelle N.] Univ Chicago, Dept Pediat, Chicago, IL USA; [Naylor, Rochelle N.] Univ Chicago, Dept Med, Chicago, IL USA; [Ozkan, Bige; Rooney, Mary R.; Wallace, Amelia S.; Selvin, Elizabeth] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA; [Ozkan, Bige] Johns Hopkins Sch Med, Ciccarone Ctr Prevent Cardiovasc Dis, Baltimore, MD USA; [Pilla, Scott J.; Kanbour, Sarah; Sarkar, Sudipa; Mathioudakis, Nestoras] Johns Hopkins Univ, Dept Med, Baltimore, MD USA; [Pilla, Scott J.] Johns Hopkins Univ, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, Baltimore, MD USA; [Prystupa, Katsiaryna; Schoen, Martin; Wagner, Robert] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, Inst Clin Diabetol, German Diabet Ctr, Dusseldorf, Germany; [Prystupa, Katsiaryna; Schoen, Martin; Stefan, Norbert; Wagner, Robert] German Ctr Diabet Res DZD, Neuherberg, Germany; [Raghavan, Sridharan] Eastern Colorado Hlth Care Syst, US Dept Vet Affairs, Sect Acad Primary Care, Aurora, CO USA; [Raghavan, Sridharan] Univ Colorado, Dept Med, Sch Med, Aurora, CO USA; [Rooney, Mary R.; Wallace, Amelia S.; Wang, Caroline C.; Ray, Debashree; Selvin, Elizabeth] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA; [Schoen, Martin; Stefan, Norbert] Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis IDM, Neuherberg, Germany; [Schoen, Martin] Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Bratislava, Slovakia; [Sevilla-Gonzalez, Magdalena] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA USA; [Svalastoga, Pernille; Aukrust, Ingvild; Molnes, Janne; Njolstad, Pal Rasmus] Univ Bergen, Dept Clin Sci, Mohn Ctr Diabet Precis Med, Bergen, Norway; [Svalastoga, Pernille; Njolstad, Pal Rasmus] Haukeland Hosp, Children & Youth Clin, Bergen, Norway; [Takele, Wubet Worku; Ukke, Gebresilasea Gendisha; Lim, Siew S.] Monash Univ, Eastern Hlth Clin Sch, Melbourne, Vic, Australia; [Tam, Claudia Ha-ting; Huang, Chuiguo; Yu, Gechang; Zhang, Yingchai; Ma, Ronald C. W.] Chinese Univ Hong Kong, Lab Mol Epidemiol Diabet, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China; [Tam, Claudia Ha-ting; Ma, Ronald C. W.] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China; [Tosur, Mustafa; Redondo, Maria J.] Baylor Coll Med, Dept Pediat, Houston, TX USA; [Tosur, Mustafa; Urazbayeva, Marzhan; Redondo, Maria J.] Texas Childrens Hosp, Div Pediat Diabet & Endocrinol, Houston, TX USA; [Tosur, Mustafa] ARS, Childrens Nutr Res Ctr, USDA, Houston, TX USA; [Wong, Jessie J.; Hood, Korey K.] Stanford Univ, Sch Med, Stanford, CA USA; [Yamamoto, Jennifer M.] Univ Manitoba, Internal Med, Winnipeg, MB, Canada; [Amouyal, Chloe] AP HP, Dept Diabetol, Paris, France; [Amouyal, Chloe] Sorbonne Univ, INSERM, NutriOm Team, Paris, France; [Bonham, Maxine P.; Leung, Gloria K. W.] Monash Univ, Dept Nutr Dietet & Food, Melbourne, Vic, Australia; [Chen, Mingling] Monash Univ, Monash Ctr Hlth Res & Implementat, Clayton, Vic, Australia; [Cheng, Feifei] Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China; [Chikowore, Tinashe] Univ Witwatersrand, Fac Hlth Sci, Dept Paediat, MRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa; [Chikowore, Tinashe] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA; [Chikowore, Tinashe] Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa; [Chivers, Sian C.; White, Sara L.] Kings Coll London, Dept Women & Childrens Hlth, London, England; [Dabelea, Dana; Boyle, Kristen; Perng, Wei] Univ Colorado, Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Anschutz Med Campus, Aurora, CO USA; [Dickens, Laura T.] Univ Chicago, Kovler Diabet Ctr, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL USA; [DiMeglio, Linda A.] Indiana Univ Sch Med, Dept Pediat, Riley Hosp Children, Indianapolis, IN USA; [Evans-Molina, Carmella] Richard L Roudebush VAMC, Indianapolis, IN USA; [Fernandez-Balsells, Maria Merce] IdIBGi, Biomed Res Inst Girona, Girona, Spain; [Fernandez-Balsells, Maria Merce] Univ Hosp Dr Josep Trueta, Diabet Endocrinol & Nutr Unit Girona, Girona, Spain; [Fitzpatrick, Stephanie L.] Northwell Hlth, Feinstein Inst Med Res, Inst Hlth Syst Sci, Manhasset, NY USA; [Gitelman, Stephen E.] Univ Calif San Francisco, San Francisco, CA USA; [Goodarzi, Mark O.] Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA USA; [Goodarzi, Mark O.] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA USA; [Grieger, Jessica A.; Habibi, Nahal; Liu, Kai; Pathirana, Maleesa; Quinteros, Alejandra] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA, Australia; [Grieger, Jessica A.; Habibi, Nahal; Pathirana, Maleesa; Zhou, Shao J.] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia; [Guasch-Ferre, Marta] Univ Copenhagen, Dept Publ Hlth, Fac Hlth & Med Sci, Copenhagen, Denmark; [Guasch-Ferre, Marta] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark; [Hoag, Benjamin] Sanford Childrens Hosp, Dept Pediat, Div Endocrinol & Diabet, Sioux Falls, SD USA; [Hoag, Benjamin] Univ South Dakota, Sch Med, E Clark St, Vermillion, SD USA; [Johnson, Randi K.; Stanislawski, Maggie A.] Univ Colorado, Dept Biomed Informat, Anschutz Med Campus, Aurora, CO USA; [Johnson, Randi K.] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA; [Jones, Angus G.; Hattersley, Andrew T.; Oram, Richard] Royal Devon Univ Healthcare NHS Fdn Trust, Exeter, Devon, England; [Koivula, Robert W.; Owen, Katharine R.; Franks, Paul W.] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England; [Leong, Aaron; Meigs, James B.] Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA USA; [Libman, Ingrid M.] UPMC Childrens Hosp Pittsburgh, Pittsburgh, PA USA; [Long, S. Alice] Benaroya Res Inst, Ctr Translat Immunol, Seattle, WA USA; [Lowe, William L., Jr.] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL USA; [Morton, Robert W.] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada; [Morton, Robert W.; de Souza, Russell; Sherifali, Diana] Populat Hlth Res Inst, Hamilton, ON, Canada; [Morton, Robert W.; Franks, Paul W.] Novo Nordisk Fdn, Dept Translat Med, Med Sci, Hellerup, Denmark; [Motala, Ayesha A.] Univ KwaZulu Natal, Dept Diabet & Endocrinol, Nelson R Mandela Sch Med, Durban, South Africa; [Onengut-Gumuscu, Suna; Rich, Stephen S.] Univ Virginia, Dept Publ Hlth Sci, Ctr Publ Hlth Genom, Charlottesville, VA USA; [Pankow, James S.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA; [Pazmino, Sofia; Steenackers, Nele; Van der Schueren, Bart] Katholieke Univ Leuven, Dept Chron Dis & Metab Clin & Expt Endocrinol, Leuven, Belgium; [Petrie, John R.] Univ Glasgow, Sch Hlth & Wellbeing, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland; [Powe, Camille E.] Massachusetts Gen Hosp, Dept Obstet Gynecol & Reprod Biol, Boston, MA USA; [Jain, Rashmi] Sanford Childrens Specialty Clin, Sioux Falls, SD USA; [Jain, Rashmi; Griffin, Kurt] Univ South Dakota, Dept Pediat, Sanford Sch Med, Sioux Falls, SD USA; [Ray, Debashree] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA; [Ried-Larsen, Mathias] Rigshosp, Ctr Phys Act Res, Copenhagen, Denmark; [Ried-Larsen, Mathias] Univ Southern Denmark, Inst Sports & Clin Biomech, Odense, Denmark; [Saeed, Zeb] Indiana Univ Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Indianapolis, IN USA; [Kanbour, Sarah] AMAN Hosp, Doha, Qatar; [Scholtens, Denise M.] Northwestern Univ, Div Biostat, Feinberg Sch Med, Dept Prevent Med, Chicago, IL USA; [Sheu, Wayne Huey-Herng] Natl Hlth Res Inst, Inst Mol & Genom Med, Zhunan, Taiwan; [Sheu, Wayne Huey-Herng] Taichung Vet Gen Hosp, Div Endocrinol & Metab, Taichung, Taiwan; [Sheu, Wayne Huey-Herng] Taipei Vet Gen Hosp, Div Endocrinol & Metab, Taipei, Taiwan; [Speake, Cate] Benaroya Res Inst, Ctr Intervent Immunol, Seattle, WA USA; [Steck, Andrea K.; Gottlieb, Peter A.] Univ Colorado, Barbara Davis Ctr Diabet, Anschutz Med Campus, Aurora, CO USA; [Stefan, Norbert] Univ Hosp Tubingen, Tubingen, Germany; [Stoy, Julie] Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark; [Taylor, Rachael] Univ Newcastle, Newcastle Upon Tyne, Tyne & Wear, England; [Tye, Sok Cin] Harvard Med Sch, Sect Genet, Joslin Diabet Ctr, Boston, MA USA; [Tye, Sok Cin] Harvard Med Sch, Sect Epidemiol, Joslin Diabet Ctr, Boston, MA USA; [Tye, Sok Cin] Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands; [Urazbayeva, Marzhan] Baylor Coll Med, Gastroenterol, Houston, TX USA; [Van der Schueren, Bart] Univ Hosp Leuven, Dept Endocrinol, Leuven, Belgium; [Vatier, Camille] Sorbonne Univ, INSERM, U938, St Antoine Res Ctr,Inst Cardiometab & Nutr, Paris, France; [Vatier, Camille] St Antoine Univ Hosp, AP HP, Dept Endocrinol Diabetol & Reprod Endocrinol, St Antoine Univ Hosp,Natl Reference Ctr Rare Dis, Paris, France; [Wentworth, John M.] Royal Melbourne Hosp, Dept Endocrinol & Diabet, Parkville, Vic, Australia; [Wentworth, John M.] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia; [Wentworth, John M.] Univ Melbourne, Dept Med, Parkville, Vic, Australia; [Hannah, Wesley] Deakin Univ, Melbourne, Vic, Australia; [Hannah, Wesley] Madras Diabet Res Fdn, Dept Epidemiol, Chennai, Tamil Nadu, India; [White, Sara L.] Guys & St Thomas Hosp NHS Fdn Trust, Dept Endocrinol & Diabet, London, England; [Zhou, Shao J.] Univ Adelaide, Sch Agr Food & Wine, Adelaide, SA, Australia; [Beltrand, Jacques; Polak, Michel] Inst Cochin, INSERM, U10116, Paris, France; [Beltrand, Jacques; Polak, Michel] Univ Paris, Hop Necker Enfants Malad, APHP Ctr, Pediat Endocrinol & Diabet, Paris, France; [Aukrust, Ingvild; Molnes, Janne] Haukeland Hosp, Dept Med Genet, Bergen, Norway; [Maloney, Kristin A.; Pollin, Toni I.] Univ Maryland, Dept Med, Sch Med, Baltimore, MD USA; [Pomares-Millan, Hugo] Geisel Sch Med Dartmouth, Dept Epidemiol, Hanover, NH USA; [Provenzano, Michele] Alma Mater Studiorum Univ Bologna, Nephrol Dialysis & Renal Transplant Unit, IRCCS Azienda Osped Univ Bologna, Bologna, Italy; [Saint-Martin, Cecile] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Med Genet, Paris, France; [Zhang, Cuilin] Natl Univ Singapore, Global Ctr Asian Womens Hlth, Yong Loo Lin Sch Med, Singapore, Singapore; [Zhang, Cuilin] Natl Univ Singapore, Dept Obstet & Gynecol, Yong Loo Lin Sch Med, Singapore, Singapore; [Zhu, Yeyi] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA; [Zhu, Yeyi] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA; [Auh, Sungyoung; Brown, Rebecca J.] NIDDK, NIH, Bethesda, MD USA; [de Souza, Russell] McMaster Univ, Fac Hlth Sci, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada; [Fawcett, Andrea J.; Josefson, Jami L.] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Feinberg Sch Med, Chicago, IL USA; [Fawcett, Andrea J.] Dept Clin & Org Dev, Chicago, IL USA; [Gruber, Chandra] Amer Diabet Assoc, Arlington, VA USA; [Mekonnen, Eskedar Getie] Univ Gondar, Coll Med & Hlth Sci, Gondar, Ethiopia; [Mekonnen, Eskedar Getie] Univ Antwerp, Global Hlth Inst, Fac Med & Hlth Sci, Antwerp, Belgium; [Mixter, Emily; Philipson, Louis H.; Greeley, Siri Atma W.] Univ Chicago, Dept Med, Chicago, IL USA; [Mixter, Emily; Philipson, Louis H.; Greeley, Siri Atma W.] Univ Chicago, Kovler Diabet Ctr, Chicago, IL USA; [Sherifali, Diana] McMaster Univ, Sch Nursing, Fac Hlth Sci, Hamilton, ON, Canada; [Eckel, Robert H.] Univ Colorado, Div Endocrinol, Diabet, Metab, Aurora, CO USA; [Nolan, John J.] Trinity Coll Dublin, Sch Med, Dept Clin Med, Dublin, Ireland; [Nolan, John J.] Wexford Gen Hosp, Dept Endocrinol, Wexford, Ireland; [Billings, Liana K.] NorthShore Univ HealthSyst, Div Endocrinol, Skokie, IL USA; [Billings, Liana K.] Univ Chicago, Prtizker Sch Med, Dept Med, Chicago, IL USA; [Gloyn, Anna L.] Stanford Univ, Dept Genet, Stanford Sch Med, Stanford, CA USA; [Gomez, Maria F.] Aarhus Univ, Fac Hlth, Aarhus, Denmark; [Greeley, Siri Atma W.] Univ Chicago, Dept Pediat, Chicago, IL USA; [Griffin, Kurt] Sanford Res, Sioux Falls, SD USA; [Hirsch, Irl B.] Univ Washington, Sch Med, Seattle, WA USA; [Hivert, Marie-France] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA USA; [Hivert, Marie-France] Univ Sherbrooke, Dept Med, Sherbrooke, PQ, Canada; [Kwak, Soo Heon] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul Natl Univ Hosp, Seoul, South Korea; [Laffel, Lori M.] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA USA; [Loos, Ruth J. F.] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA; [Meigs, James B.] Broad Inst, Cambridge, MA USA; [Misra, Shivani] Imperial Coll London, Div Metab Digest & Reprod, London, England; [Misra, Shivani] Imperial Coll Healthcare NHS Trust, Dept Diabet & Endocrinol, London, England; [Mohan, Viswanathan] Madras Diabet Res Fdn & Dr Mohans Diabet Special, Dept Diabetol, Chennai, Tamil Nadu, India; [Murphy, Rinki] Univ Auckland, Dept Med, Fac Med & Hlth Sci, Auckland, New Zealand; [Murphy, Rinki] Whatu Ora Hlth New Zealand, Auckland Diabet Ctr, Auckland, New Zealand; [Murphy, Rinki] Hlth New Zealand, Whatu Ora Counties, Med Bariatr Serv, Auckland, New Zealand; [Owen, Katharine R.] Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England; [Ozanne, Susan E.] Univ Cambridge, Metab Res Labs, Cambridge, England; [Ozanne, Susan E.] Wellcome MRC Inst Metab Sci, MRC Metab Dis Unit, Cambridge, England; [Pollin, Toni I.] Univ Maryland, Dept Epidemiol & Publ Hlth, Sch Med, Baltimore, MD USA; [Pop-Busui, Rodica] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI USA; [Pratley, Richard E.] AdventHlth Translat Res Inst, Orlando, FL USA; [Redman, Leanne M.] Pennington Biomed Res Ctr, Baton Rouge, LA USA; [Semple, Robert K.] Univ Edinburgh, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland; [Sherr, Jennifer L.] Yale Sch Med, New Haven, CT USA; [Sweeting, Arianne] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia; [Sweeting, Arianne] Royal Prince Alfred Hosp, Dept Endocrinol, Sydney, NSW, Australia; [Vesco, Kimberly K.] Kaiser Permanente Northwest, Kaiser Permanente Ctr Hlth Res, Portland, OR USA; [Vilsboll, Tina] Steno Diabet Ctr Copenhagen, Clinial Res, Herlev, Denmark; [Vilsboll, Tina] Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark; [Wagner, Robert] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Endocrinol & Diabetol, Dusseldorf, Germany"

通信作者："Franks, PW (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.; Franks, PW (通讯作者)，Lund Univ, Diabet Ctr, Dept Clin Sci, Malmo, Sweden.; Franks, PW (通讯作者)，Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.; Franks, PW (通讯作者)，Novo Nordisk Fdn, Dept Translat Med, Med Sci, Hellerup, Denmark."

来源：NATURE MEDICINE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001085074500001

JCR分区：Q1

影响因子：58.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

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摘要："Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine. A systematic review of evidence, across the key pillars of prevention, diagnosis, treatment and prognosis, outlines milestones that need to be met to enable the broad clinical implementation of precision medicine in diabetes care."

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