Different subtypes of gestational diabetes mellitus are associated with distinct perinatal outcomes in twin pregnancies

作者全名："Wen, Li; Chen, Ya; Liu, Taihang; Wang, Yingxiong; Baker, Philip N.; Qi, Hongbo; Wang, Lan"

作者地址："[Wen, Li; Chen, Ya; Qi, Hongbo; Wang, Lan] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Wen, Li; Chen, Ya; Qi, Hongbo; Wang, Lan] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China; [Liu, Taihang; Wang, Yingxiong] Chongqing Med Univ, Sch Basic Med Sci, Chongqing 400016, Peoples R China; [Baker, Philip N.] Univ Leicester, Coll Life Sci, Leicester LE1 7RH, England; [Qi, Hongbo] Chongqing Med Univ, State Key Lab Maternal & Fetal Med Chongqing Munic, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Qi, HB; Wang, L (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China."

来源：DIABETES RESEARCH AND CLINICAL PRACTICE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001085350600001

JCR分区：Q1

影响因子：6.1

年份：2023

卷号：204

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Gestational diabetes mellitus; Fasting glucose; Post-load glucose; Maternal outcomes; Neonatal outcomes; Twin pregnancies

摘要："Aims: To determine whether different gestational diabetes mellitus (GDM) subtypes are associated with distinct perinatal outcomes in twin pregnancies.Materials: This retrospective cohort study enrolled women with twin pregnancies who gave birth at a tertiary hospital between January 2017 and December 2022. GDM was diagnosed by the IADPSG diagnostic criteria. Three subtypes of GDM were defined as only abnormal fasting glucose (OAFG) values, only abnormal post-load glucose (OAPG) values and abnormal combined fasting and post-load glucose (ACFPG) values. Logistic regression or generalized estimation equation models were used to test the correlation of subtypes of GDM and perinatal outcomes.Results: GDM with OAPG had a slightly higher risk for preterm delivery (PTD) at <37 gestational weeks (aOR 1.22, 95 %CI 1.01-1.47) and neonatal intensive care unit (NICU) admission (aOR 1.31, 95 %CI 1.09-1.57). GDM with ACFPG were associated with PTD at <37 gestational weeks (aOR 1.42, 95 %CI 1.06-1.89) and PTD at <34 gestational weeks (aOR 1.65, 95 % CI 1.14-2.39). GDM with OAFG had a lower risk of being small-for-gestational age (SGA) (aOR 0.48, 95 % CI 0.26-0.92).Conclusions: Different subtypes of GDM are associated with distinct perinatal outcomes. Only abnormal fasting glucose levels may be responsible for reduced the risk of SGA neonates."

基金机构：Chongqing Science and Technology Commission [CSTB2023NSCQ-MSX0384]

基金资助正文：<BOLD>Funding</BOLD> This study was supported by the Chongqing Science and Technology Commission (CSTB2023NSCQ-MSX0384) .