Young obese patients may benefit from GnRH-a long protocol contributing to higher implantation rate and live birth rate of fresh IVF-ET cycles

作者全名："Wan, Qi; Qian, Yue; Xia, Ming-Jing; Tan, Li; Lv, Xing-Yu; Meng, Xiang-Qian; Ding, Yu-Bin; Zhong, Zhao-Hui; Geng, Li-Hong"

作者地址："[Wan, Qi; Xia, Ming-Jing; Lv, Xing-Yu; Meng, Xiang-Qian; Geng, Li-Hong] Chengdu Jinjiang Hosp Womens & Childrens Hlth, Chengdu 610011, Peoples R China; [Wan, Qi] Sichuan Univ, West China Hosp 2, Dept Gynecol & Obstet, Chengdu, Peoples R China; [Wan, Qi] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Peoples R China; [Qian, Yue; Zhong, Zhao-Hui] Chongqing Med Univ, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Sch Publ Hlth & Management,Dept Epidemiol, Chongqing 400016, Peoples R China; [Tan, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Reprod Med, Chongqing 400016, Peoples R China; [Ding, Yu-Bin] Chongqing Med Univ, Sch Publ Hlth & Management, Joint Int Res Lab Reprod & Dev, Minist Educ China, Chongqing 400016, Peoples R China; [Ding, Yu-Bin] Changsha Med Univ, Dept Pharmacol, Academician Workstat, Changsha 410219, Peoples R China"

通信作者："Geng, LH (通讯作者)，Chengdu Jinjiang Hosp Womens & Childrens Hlth, Chengdu 610011, Peoples R China.; Zhong, ZH (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Sch Publ Hlth & Management,Dept Epidemiol, Chongqing 400016, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001086053700001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：Obesity; IVF-ET; COH protocol; Pregnancy outcome

摘要："Introduction: Obesity has detrimental influences on women reproductive health. There is little experience in optimizing controlled ovarian hyperstimulation (COH) protocols to treat Chinese obese patients who are undergoing in vitro fertilization and embryo transfer (IVF-ET) therapy. Methods: The clinical outcome differences were retrospectively analyzed among obese patients who received gonadotrophin-releasing hormone agonist (GnRH-a), GnRH antagonist (GnRH-ant), micro dose GnRH-a (mGnRH-a) and GnRH-a long protocol in IVF-ET cycle at Chengdu Jinjiang Hospital for Women's and Children's Health from January 2014 to December 2019. Results: The transplantation rate of the GnRH-a long protocol group (59.1%) was higher than that of the GnRH-ant (25.9%) and mGnRH-a (36.7%) groups. The total live birth rate of the GnRH-a long protocol group (46.2%) was higher than that of the GnRH-a group (25.9%) and GnRH-ant group (40.3%). The total number of frozen embryos in the GnRH-ant group was higher than in the other groups (P < 0.05). After adjusting for confounding factors, the logistic regression analysis showed that the GnRH-a long protocol group had higher probabilities of biochemical pregnancy, clinical pregnancy, and live birth than the GnRH-a protocol group. The Gn dose in the mGnRH-a group was higher than the other three groups. Whether single or twin, there were similar neonatal outcomes among the four groups including premature birth rate, Apgar score, newborn weight, and length.Conclusion: For young obese patients undergoing IVF-ET, the GnRH-a long protocol for COH gives better pregnancy outcomes."

基金机构：General Program Science Foundation of Sichuan Province [2018JY0357]; Medical Science and Technology Project of Sichuan Provincial Health Committee [21PJ166]

基金资助正文：This study was funded by the General Program Science Foundation of Sichuan Province (NO.2018JY0357) and the Medical Science and Technology Project of Sichuan Provincial Health Committee (21PJ166) .