A Case Report of Adalimumab Successfully Treated a Severe Plaque Psoriasis Patient with Psoriatic End-Stage Renal Disease

作者全名："Xu, Jing; Chen, Aijun; Peng, Yuting; Wen, Zhuyuan; Huang, Kun; Wang, Ping"

作者地址："[Xu, Jing; Chen, Aijun; Peng, Yuting; Wen, Zhuyuan; Huang, Kun; Wang, Ping] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, Chongqing, Peoples R China; [Wen, Zhuyuan] Chongqing Med Univ, Coll Pediat, Chongqing, Peoples R China; [Wang, Ping] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Wang, P (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China."

来源：CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY

ESI学科分类：　

WOS号：WOS:001086187400001

JCR分区：Q2

影响因子：2.3

年份：2023

卷号：16

期号：　

开始页：2841

结束页：2846

文献类型：Article

关键词：psoriasis; end-stage kidney disease; chronic kidney disease; adalimumab; biologics

摘要："Psoriasis is a common chronic inflammatory skin disease that manifests itself not only on the skin but also on various tissues and organs of the body. While some psoriasis co-morbidities have been investigated, little is known about its association with impairment of renal function. In 2005, the concept of psoriatic nephropathy was first introduced by Indian nephrologists, suggesting a potential relationship between psoriasis and kidney disease. Adalimumab, a fully human recombinant immunoglobulin G1 monoclonal antibody against tumor necrosis factor (TNF)-alpha, has been shown to be a safe and effective treatment for patients with moderate to severe psoriasis. Here, we present a case of severe plaque psoriasis accompanied with end-stage renal disease (ESRD) treated with adalimumab. Following the case presentation is a discussion of the relationship between psoriasis and chronic kidney disease (CKD) / ESRD and the possible role of biologics in psoriasis-related kidney damage. The aim of this report is to increase dermatologists' awareness of psoriatic nephropathy as a complication of psoriasis and to raise awareness of the use of biologics in psoriasis."

基金机构：national natural science foundation of China [NSFC 82103733]

基金资助正文："This research was funded by national natural science foundation of China, grant number NSFC 82103733."