"Prevalence and associations of sarcopenia, obesity and sarcopenic obesity in end-stage knee osteoarthritis patients"

作者全名："Liao, Junyi; Chen, Jie; Xu, Wei; Chen, Jia; Liang, Xi; Cheng, Qiang; Tang, Yongli; Huang, Wei"

作者地址："[Liao, Junyi; Chen, Jie; Xu, Wei; Liang, Xi; Cheng, Qiang; Tang, Yongli; Huang, Wei] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing 400016, Peoples R China; [Liao, Junyi; Xu, Wei; Liang, Xi; Cheng, Qiang; Tang, Yongli; Huang, Wei] Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China; [Chen, Jia] Chongqing Med Univ, Affiliated Hosp 1, Dept Nutriol, Chongqing 400016, Peoples R China"

通信作者："Cheng, Q; Tang, YL; Huang, W (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped Surg, Chongqing 400016, Peoples R China.; Cheng, Q; Tang, YL; Huang, W (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing 400016, Peoples R China."

来源：JOURNAL OF HEALTH POPULATION AND NUTRITION

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001086567300001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：42

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Osteoarthritis; Sarcopenia; Obesity; Sarcopenic obesity; Body composition

摘要："Objective To identify the prevalence of obesity, sarcopenia, sarcopenic obesity in end-stage knee osteoarthritis (KOA) patients and analyze influences of obesity and sarcopenia in the progression of KOA.Methods A cross-sectional study was carried out among end-stage KOA patients who consecutively admitted to Orthopedic Department for TKA. We suppose that the level of decreased physical activities would be influenced by unilateral or bilateral KOA. Patient information, albumin, hemoglobin, pace, step frequency, number of comorbid conditions were collected. Bioelectrical impedance analyzer was used to analyze body composition. Obesity, sarcopenia, sarcopenic obesity rate were analyzed with accepted diagnosis criteria. Correlations between body mass index (BMI) or age and fat mass (FM), appendicular skeletal muscle mass (ASM) were analyzed.Results 138 patients (male 30, female 108) in southwest of China including 67 patients with unilateral KOA and 71 patients with bilateral KOA were analyzed. No statistic difference was found in mean albumin, prealbumin and hematocrystallin, body composition values and number of comorbid conditions. We found that BMI was positively correlated with FM (Male: R-2 = 0.7177, p < 0.0001, Female: R-2= 0.8898, p < 0.0001), ASM (Male: R-2 = 0.2640, p = 0.0037, Female: R-2 = 0.2102, p < 0.0001), FM index (FMI) (Male: R-2 = 0.6778, p < 0.0001, Female: R-2= 0.8801, p < 0.0001), and ASM index (ASMI) (Male: R-2 = 0.3600, p = 0.0005, Female: R-2 = 0.4208, p < 0.0001) in end-stage KOA patients. However, age was not obviously correlated with FM or FMI (Male: FM, R-2 = 0.006911, p = 0.3924; FMI, R-2 = 0.7554, p = 0.0009196; Female: FM, R-2= 0.001548, p = 0.8412; FMI, R-2 = 0.002776, p = 0.7822). And slightly negatively correlated with ASM (Male: R-2 = 0.05613, p = 0.0136, Female: R-2 = 0.01327, p = 0.5433) and ASMI (Male: R-2 = 0.02982, p = 0.3615; Female: R-2 = 0.03696, p = 0.0462). The prevalence of obesity, sarcopenia and obesity sarcopenia differs according to different diagnosis criteria. No difference in the occurrence rate of obesity was found between bilateral KOA and unilateral KOA patients, and occurrence rates of sarcopenia and sarcopenic obesity were statistically higher in bilateral KOA than that in unilateral KOA patients.Conclusions Obesity, sarcopenia and sarcopenic obesity are highly prevalent in end-stage KOA patients, sarcopenic obesity are more prevalent in bilateral KOA patients than that in unilateral KOA patients."

基金机构：The authors express their sincere gratitude to medical and nursing stuff of Orthopaedic surgery of The First Affiliated Hospital of Chongqing Medical University and all patients who participated in the study.; medical and nursing stuff of Orthopaedic surgery of The First Affiliated Hospital of Chongqing Medical University

基金资助正文：The authors express their sincere gratitude to medical and nursing stuff of Orthopaedic surgery of The First Affiliated Hospital of Chongqing Medical University and all patients who participated in the study.