Long-term exposure to ambient ozone at workplace is positively and non-linearly associated with incident hypertension and blood pressure: longitudinal evidence from the Beijing-Tianjin-Hebei medical examination cohort

作者全名："Hu, Songhua; Xu, Ximing; Li, Chunjun; Zhang, Li; Xing, Xiaolong; He, Jiangshan; Guo, Pei; Zhang, Jingbo; Niu, Yujie; Chen, Shuo; Zhang, Rong; Liu, Feng; Ma, Shitao; Zhang, Mianzhi; Guo, Fenghua; Zhang, Minying"

作者地址："[Hu, Songhua] Nankai Univ, Sch Stat & Data Sci, Tianjin, Peoples R China; [Hu, Songhua; Xu, Ximing] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Big Data Ctr Childrens Med Care, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Li, Chunjun] Tianjin Union Med Ctr, Tianjin, Peoples R China; [Zhang, Li] Tianjin First Cent Hosp, Tianjin, Peoples R China; [Xing, Xiaolong; He, Jiangshan; Guo, Pei; Guo, Fenghua; Zhang, Minying] Nankai Univ, Sch Med, Tianjin, Peoples R China; [Zhang, Jingbo; Chen, Shuo; Liu, Feng] Beijing Phys Examinat Ctr, Beijing, Peoples R China; [Niu, Yujie; Zhang, Rong; Ma, Shitao] Hebei Key Lab Environm & Human Hlth, Shijiazhuang, Peoples R China; [Niu, Yujie; Zhang, Rong; Ma, Shitao] Hebei Med Univ, Dept Occupat Hlth & Environm Hlth, Shijiazhuang, Peoples R China; [Zhang, Mianzhi] Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China; [Zhang, Mianzhi] Tianjin Acad Tradit Chinese Med, Affiliated Hosp, Tianjin, Peoples R China"

通信作者："Zhang, MY (通讯作者)，Nankai Univ, Sch Med, Tianjin, Peoples R China."

来源：BMC PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001086774200006

JCR分区：Q1

影响因子：3.5

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Air pollution; Ozone; Hypertension; Blood pressure; Occupational exposure; Longitudinal studies

摘要："Background There is limited longitudinal evidence on the hypertensive effects of long-term exposure to ambient O-3. We investigated the association between long-term O-3 exposure at workplace and incident hypertension, diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure (PP), and mean arterial pressure (MAP) in general working adults.Methods We conducted a cohort study by recruiting over 30,000 medical examination attendees through multistage stratified cluster sampling. Participants completed a standard questionnaire and comprehensive medical examination. Three-year ambient O-3 concentrations at each employed participant's workplace were estimated using a two-stage machine learning model. Mixed-effects Cox proportional hazards models and linear mixed-effects models were used to examine the effect of O-3 concentrations on incident hypertension and blood pressure parameters, respectively. Generalized additive mixed models were used to explore non-linear concentration-response relationships.Results A total of 16,630 hypertension-free working participants at baseline finished the follow-up. The mean (SD) O-3 exposure was 45.26 (2.70) ppb. The cumulative incidence of hypertension was 7.11 (95% CI: 6.76, 7.47) per 100 person-years. Long-term O-3 exposure was independently, positively and non-linearly associated with incident hypertension (Hazard ratios (95% CI) for Q2, Q3, and Q4 were 1.77 (1.34, 2.36), 2.06 (1.42, 3.00) and 3.43 (2.46, 4.79), respectively, as compared with the first quartile (Q1)), DBP (beta (95% CI) was 0.65 (0.01, 1.30) for Q2, as compared to Q1), SBP (beta (95% CI) was 2.88 (2.00, 3.77), 2.49 (1.36, 3.61) and 2.61 (1.64, 3.58) for Q2, Q3, and Q4, respectively), PP (beta (95% CI) was 2.12 (1.36, 2.87), 2.03 (1.18, 2.87) and 2.14 (1.38, 2.90) for Q2, Q3, and Q4, respectively), and MAP (beta (95% CI) was 1.39 (0.76, 2.02), 1.04 (0.24, 1.84) and 1.12 (0.43, 1.82) for Q2, Q3, and Q4, respectively). The associations were robust across sex, age, BMI, and when considering PM2.5 and NO2.Conclusions To our knowledge, this is the first cohort study in the general population that demonstrates the non-linear hypertensive effects of long-term O-3 exposure. The findings are particularly relevant for policymakers and researchers involved in ambient pollution and public health, supporting the integration of reduction of ambient O-3 into public health interventions."

基金机构：National Key Research and Development Program of China [2016YFC0900600/2016YFC0900604]

基金资助正文：This work was supported by the National Key Research and Development Program of China [grant number 2016YFC0900600/2016YFC0900604].