Electrochemical Immunosensor Based on Al-TCPP Nanomaterial Adsorption Aggregation Signal Amplification for the Detection of Dengue Virus NS1 Protein

作者全名："Zhang, Zixuan; Li, Wei; Liu, Jie; Li, Ying; Qiu, Jingfu; Li, Chaorui"

作者地址："[Zhang, Zixuan; Li, Wei; Liu, Jie; Li, Ying; Qiu, Jingfu; Li, Chaorui] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China"

通信作者："Li, CR (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China."

来源：ELECTROCATALYSIS

ESI学科分类：CHEMISTRY

WOS号：WOS:001087736900001

JCR分区：Q2

影响因子：3.1

年份：2024

卷号：15

期号：1

开始页：10

结束页：19

文献类型：Article

关键词：Dengue virus NS1; Al-TCPP/MB; Electrochemistry; Adsorption; Electrochemical immunosensor

摘要："To detect the dengue virus NS1 protein with high sensitivity, this research suggests an electrochemical immunosensor based on the Al-TCPP adsorption aggregation signal amplification approach. We created a type of metal-organic framework (MOF) material called astrophytum myriostigma, which resembles a cactus plant and has a large specific surface area. In addition, it can produce electrostatic attraction with the amino groups on methylene blue (MB), firmly fix MB on the MOF material, and manage MB reunion after adsorption, which is helpful for electron transmission and amplifies the electrical signal. The cationic dye methylene blue has redox characteristics. It possesses a high electron transfer rate, electrochemical reversibility, and strong biocompatibility. The generated electrochemical immunosensor has good reproducibility and stability, and the relationship between the analyte concentration and electrical signal strength is linear. The suggested immunosensor has a broad detection range from 10 fg/mL to 100 ng/mL with a low detection limit of 9.12 fg/mL under ideal conditions."

基金机构："Natural Science Foundation of Chongqing, China [cstc2019jcyj-msxmX0121]"

基金资助正文："This work was supported by the Natural Science Foundation of Chongqing, China (No. cstc2019jcyj-msxmX0121)."