Influence of Goniotomy Size on Treatment Safety and Efficacy for Primary Open-Angle Glaucoma: A Multicenter Study

作者全名："Zhang, Yu; Yu, Ping; Zhang, Yingzhe; Sugihara, Kazunobu; Zhu, Xiaomin; Zhang, Yao; Yang, Xiao; Li, Xiaoyan; Liu, Yacong; Zhang, Hengli; Yan, Xiaowei; Zhang, Hengkai; Lin, Fengbin; Song, Yunhe; Gao, Xinbo; Yuan, Huiping; Tang, Guangxian; Zhou, Wenzong; Fan, Sujie; Dang, Guangfu; Tang, Li; Chen, Weirong; Wang, Ningli; Park, Ki ho; Barton, Keith; Aung, Tin; Lam, Dennis S. C.; Weinreb, Robert N.; Xie, Lin; Tanito, Masaki; Zeng, Liuzhi; Zhang, Xiulan"

作者地址："[Zhang, Yu; Lin, Fengbin; Song, Yunhe; Gao, Xinbo; Chen, Weirong; Zhang, Xiulan] Sun Yat Sn Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr,Guangdong Prov Key Lab Oph, Guangdong Prov Clin Re search Ctr Ocular Dis, Guangzhou, Guangdong, Peoples R China; [Yu, Ping; Zeng, Liuzhi] Chengdu First Peoples Hosp, Dept Ophthalmol, Chengdu, Sichuan, Peoples R China; [Sugihara, Kazunobu; Tanito, Masaki] Shimane Univ, Fac Med, Dept Ophthalmol, Izumo, Shimane, Japan; [Zhu, Xiaomin; Xie, Lin] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 3, Chongqing, Peoples R China; [Zhang, Yao; Tang, Li] Sichuan Univ, Dept Ophthalmol, West China Hosp, Chengdu, Sichuan, Peoples R China; [Yang, Xiao; Li, Xiaoyan; Fan, Sujie] Jinan Mingshui Eye Hosp, Jinan, Shandong, Peoples R China; [Xie, Lin] Third Hosp Handan, Handan City Eye Hosp, Dept Ophthalmol, Handan, Hebei, Peoples R China; [Liu, Yacong; Zhou, Wenzong] Cangzhou Aier Eye Hosp, Aier Eye Hosp Grp, Cangzhou, Hebei, Peoples R China; [Yang, Xiao; Tang, Guangxian] Shijiazhuang Peoples Hosp, Dept Ophthalmol, Shijiazhuang, Hebei, Peoples R China; [Zhang, Hengli; Yuan, Huiping] Harbin Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Harbin, Heilongjiang, Peoples R China; [Dang, Guangfu] Shandong First Med Uni, Affiliated Hosp 1, Dept Ophthalmol, Jinan, Shandong, Peoples R China; [Dang, Guangfu] Shandong Prov Qianfoshan Hosp, Dept Ophthalmol, Jinan, Shandong, Peoples R China; [Wang, Ningli] Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China; [Park, Ki ho] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Ophthalmol, Seoul, South Korea; [Barton, Keith] UCL Inst Ophthalmol, Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England; [Aung, Tin] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore; [Lam, Dennis S. C.] Chinese Univ Hong Kong Shenzhen, Int Eye Res Inst, Shenzhen, Peoples R China; [Weinreb, Robert N.] Univ Calif San Diego, Hamilton Glaucoma Ctr, Viterbi Family Dept Ophthalmol, La Jolla, CA USA; [Weinreb, Robert N.] Univ Calif San Diego, Shiley Eye Inst, La Jolla, CA USA; [Zhang, Xiulan] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, 7 Jinsui Rd, Guangzhou 510060, Peoples R China; [Zeng, Liuzhi] Chengdu First Peoples Hosp, Dept Ophthalmol, Chengdu 610000, Peoples R China"

通信作者："Zhang, Y (通讯作者)，Sun Yat Sn Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr,Guangdong Prov Key Lab Oph, Guangdong Prov Clin Re search Ctr Ocular Dis, Guangzhou, Guangdong, Peoples R China."

来源：AMERICAN JOURNAL OF OPHTHALMOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001088464200001

JCR分区：Q1

影响因子：4.1

年份：2023

卷号：256

期号：　

开始页：118

结束页：125

文献类型：Article

关键词：　

摘要："PURPOSE: To compare the efficacy and safety of 120-, 240-, and 360-degree goniotomy (GT) with or without phacoemulsification with intraocular lens implantation (PEI) for patients with primary open-angle glaucoma (POAG). DESIGN: Multicenter, retrospective, comparative, nonrandomized interventional study. METHODS: Patients diagnosed with POAG who underwent GT with or without PEI were included, and divided into 6 groups: 1) standalone 120-degree GT (120GT); 2) standalone 240-degree GT (240GT); 3) standalone 360-degree GT (360GT); 4) PEI + 120GT; 5) PEI + 240GT; and 6) PEI + 360GT. Data on intraocular pressure (IOP), the number of ocular hypotensive medications, and complications were collected and compared. Success was defined as a postoperative IOP within the range of 6 to 18 mm Hg and a 20% reduction from baseline without further glaucoma surgery. Complete success and qualified success were defined as the above without and with ocular hypotensive medications, respectively. RESULTS: Three hundred eight eyes of 231 patients were included with a mean follow-up of 14.4 +/- 8.6 months (6.0-48.0 months). There were no significant differences in the reductions in IOP and number of medications and cumulative survival probability for complete and qualified success rates among the 3 groups of standalone GT and PEI + GT. The 360GT group had the highest proportion of hyphema with or without PEI. CONCLUSIONS: 120GT, 240GT, and 360GT with or without PEI showed similar efficacy in reducing IOP and medications used in POAG. 360GT with or without PEI was more likely to cause hyphema compared with 120GT or 240GT. 120GT with or without PEI was sufficient for treating POAG with or without cataract. (c) 2023 Elsevier Inc. All rights reserved."

基金机构：National Key R&D Program of China [2022YFC2502800]; Project of Chengdu Science and Technology Bureau [2021-YF05-00649-SN]; National Natural Science Foundation of China [81670860]; Chongqing Natural Research Foundation [cstc 2018jcyjAX0034]; Cangzhou Key Research and Development Plan Guidance Project [213106140]

基金资助正文：Funding/Support: Supported by the National Key R&D Program of China (2022YFC2502800) ; the Project of Chengdu Science and Technology Bureau (No. 2021-YF05-00649-SN) ; the National Natural Science Foundation of China (No. 81670860) ; the Chongqing Natural Research Foundation (No. cstc 2018jcyjAX0034) ; the Cangzhou Key Research and Development Plan Guidance Project (No. 213106140) . Financial Disclosures: The authors indicate no financial support or conflicts of interest. All authors attest that they meet the current ICMJE criteria for authorship.