Prelimbic area to lateral hypothalamus circuit drives social aggression

作者全名："Bai, Fuhai; Huang, Lu; Deng, Jiao; Long, Zonghong; Hao, Xianglin; Chen, Penghui; Wu, Guangyan; Wen, Huizhong; Deng, Qiangting; Bao, Xiaohang; Huang, Jing; Yang, Ming; Li, Defeng; Ren, Yukun; Zhang, Min; Xiong, Ying; Li, Hong"

作者地址："[Bai, Fuhai; Huang, Lu; Long, Zonghong; Bao, Xiaohang; Huang, Jing; Yang, Ming; Ren, Yukun; Zhang, Min; Li, Hong] Army Med Univ, Xinqiao Hosp, Dept Anesthesiol, Chongqing 400037, Peoples R China; [Deng, Jiao] Air Force Med Univ, Xijing Hosp, Dept Anesthesiol & Perioperat Med, Xian 710032, Shaanxi, Peoples R China; [Hao, Xianglin] Army Med Univ, Xinqiao Hosp, Dept Pathol, Chongqing 400037, Peoples R China; [Chen, Penghui; Wen, Huizhong; Xiong, Ying] Army Med Univ, Dept Neurobiol, Chongqing Key Lab Neurobiol, Chongqing 400038, Peoples R China; [Wu, Guangyan] Army Med Univ, Coll Basic Med Sci, Expt Ctr Basic Med, Chongqing 400038, Peoples R China; [Deng, Qiangting] Army Med Univ, Chongqing 400038, Peoples R China; [Li, Defeng] Army Med Univ, Xinqiao Hosp, Clin Med Res Ctr, Chongqing 400037, Peoples R China"

通信作者："Li, H (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Anesthesiol, Chongqing 400037, Peoples R China.; Xiong, Y (通讯作者)，Army Med Univ, Dept Neurobiol, Chongqing Key Lab Neurobiol, Chongqing 400038, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001089074200001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：26

期号：10

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Controlling aggression is a vital skill in social species such as rodents and humans and has been associated with the medial prefrontal cortex (mPFC). In this study, we showed that during aggressive behavior, the activity of GABAergic neurons in the prelimbic area (PL) of the mPFC was significantly suppressed. Specific activation of GABAergic PL neurons significantly curbed male-to-male aggression and inhibited conditioned place preference (CPP) for aggression-paired contexts, whereas specific inhibition of GABAergic PL neurons brought about the opposite effect. Moreover, GABAergic projections from PL neurons to the lateral hypothalamus (LH) orexinergic neurons mediated aggressive behavior. Finally, directly modulated LH-orexinergic neurons influence aggressive behavior. These results suggest that GABAergic PL-orexinergic LH projection is an important control circuit for intermale aggressive behavior, both of which could be targets for curbing aggression."

基金机构："National Natural Science Foundation of China [82101273, 82171265]; Postdoctoral Research Foundation of China [2021M693936]; Project of Chongqing Natural Science Foundation Postdoctoral Science Foundation [cstc2021jcyj-bshX0071]; Army Medical University Youth Incubation Program [2021XQN19, 20QNPY014]"

基金资助正文："This research was supported by grants from National Natural Science Foundation of China (82101273 to F.B. and 82171265 to H.L.) , Postdoctoral Research Foundation of China (2021M693936 to F.B.) , Project of Chongqing Natural Science Foundation Postdoctoral Science Foundation (cstc2021jcyj-bshX0071 to F.B.) , and Army Medical University Youth Incubation Program (2021XQN19 and 20QNPY014 to F.B.) ."