Role of Nasal Ventilation Function in Obstructive Sleep Apnea Syndrome in Children

作者全名："Pang, Ying; Xiao, Ling; Liang, Jia; Zhang, Feng; Yao, Hong-Bing; Shu, Yan"

作者地址："[Pang, Ying; Xiao, Ling; Liang, Jia; Zhang, Feng; Yao, Hong-Bing; Shu, Yan] Chongqing Med Univ, Dept Otolaryngol, Childrens Hosp, Chongqing, Peoples R China; [Pang, Ying; Xiao, Ling; Liang, Jia; Zhang, Feng; Yao, Hong-Bing; Shu, Yan] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Pang, Ying; Xiao, Ling; Liang, Jia; Zhang, Feng; Yao, Hong-Bing; Shu, Yan] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Pang, Ying; Xiao, Ling; Liang, Jia; Zhang, Feng; Yao, Hong-Bing; Shu, Yan] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Pang, Ying; Xiao, Ling; Liang, Jia; Zhang, Feng; Yao, Hong-Bing; Shu, Yan] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Shu, Yan] Chongqing Med Univ, Dept Otolaryngol, Childrens Hosp, 20 Jinyu Rd, Chongqing 400014, Peoples R China"

通信作者："Shu, Y (通讯作者)，Chongqing Med Univ, Dept Otolaryngol, Childrens Hosp, 20 Jinyu Rd, Chongqing 400014, Peoples R China."

来源：ENT-EAR NOSE & THROAT JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001089263100001

JCR分区：Q3

影响因子：1.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：acoustic rhinometry; children; intranasal corticosteroids; nasal resistance; oral montelukast; OSAS

摘要："Background: The association between increased nasal resistance (NR) and obstructive sleep apnea syndrome (OSAS) is controversial. The purpose of this study was to examine nasal ventilation function (NVF) in children with OSAS, with a focus on its pathogenetic role. Methods: Children were recruited and divided into the OSAS group (n = 109) and control group (n = 116). The participants underwent polysomnography (PSG), measurement of NR, and acoustic rhinometry (AR). A combination of intranasal corticosteroids (ICS) and oral montelukast (OM) was administered to 90 children with mild to moderate OSAS for 12 weeks. After excluding participants who dropped out or were lost to follow-up, there were 58 children who responded to the treatment, who were divided into 2 groups-A and B. We compared the size of the tonsil adenoids, the PSG, NR, and AR before and after treatment in the 2 groups. Results: Children aged 6 to 12 years with OSAS had significantly higher NR than the control group (P < .05). The OSAS group had a smaller nasal minimal cross-sectional area (NMCA), nasal cavity volume (NCV) from 0 to 5 cm, and nasopharyngeal volume (NPV) from 6 to 8 cm than the control group, and the difference was statistically significant (P < .05 or P < .01). A total of 58 (84.1%) children responded to the 12-week ICS+OM treatment and 11 (15.9%) children did not respond to the treatment. Effective treatment was achieved in 32 children, as evidenced by a significant reduction in tonsil adenoid size and variations in NR and AR values. There were significant improvements in NR, NMCA, and NCV in the remaining 26 children who were successfully treated, but there was no change in tonsil adenoids and NPV value. Conclusion: NVF may play an important pathogenetic role in children with OSAS."

基金机构：We are particularly grateful to all the people who have given us help on our article.

基金资助正文：We are particularly grateful to all the people who have given us help on our article.