Blood-Based Biomarkers in Intracerebral Hemorrhage

作者全名："Lv, Xin-Ni; Li, Zuo-Qiao; Li, Qi"

作者地址："[Lv, Xin-Ni; Li, Zuo-Qiao; Li, Qi] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Li, Qi] Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Li, Q (通讯作者)，Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China."

来源：JOURNAL OF CLINICAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001089393100001

JCR分区：Q1

影响因子：3

年份：2023

卷号：12

期号：20

开始页：　

结束页：　

文献类型：Review

关键词：biomarkers; intracerebral hemorrhage; hematoma growth; perihematomal edema; prognosis

摘要："Intracerebral hemorrhage (ICH) is one of the most lethal subtypes of stroke, associated with high morbidity and mortality. Prevention of hematoma growth and perihematomal edema expansion are promising therapeutic targets currently under investigation. Despite recent improvements in the management of ICH, the ideal treatments are still to be determined. Early stratification and triage of ICH patients enable the adjustment of the standard of care in keeping with the personalized medicine principles. In recent years, research efforts have been concentrated on the development and validation of blood-based biomarkers. The benefit of looking for blood candidate markers is obvious because of their acceptance in terms of sample collection by the general population compared to any other body fluid. Given their ease of accessibility in clinical practice, blood-based biomarkers have been widely used as potential diagnostic, predictive, and prognostic markers. This review identifies some relevant and potentially promising blood biomarkers for ICH. These blood-based markers are summarized by their roles in clinical practice. Well-designed and large-scale studies are required to validate the use of all these biomarkers in the future."

基金机构：Many thanks to Lan Deng for her contributions in discussing the ideas and editing the paper.

基金资助正文：Many thanks to Lan Deng for her contributions in discussing the ideas and editing the paper.