Causal effects of inflammatory bowel diseases on the risk of kidney stone disease: a two-sample bidirectional mendelian randomization

作者全名："Zhang, Huayang; Huang, Yong; Zhang, Junyong; Su, Huiyi; Ge, Chengguo"

作者地址："[Zhang, Huayang; Zhang, Junyong; Ge, Chengguo] Chongqing Med Univ, Dept Urol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Huang, Yong] Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Su, Huiyi] Chongqing Med Univ, Dept Resp Med, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Ge, CG (通讯作者)，Chongqing Med Univ, Dept Urol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：BMC UROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001089395400002

JCR分区：Q3

影响因子：2

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Kidney stone disease; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Bidirectional mendelian randomization

摘要："Background Existing epidemiological observational studies have suggested interesting but inconsistent clinical correlations between inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), and kidney stone disease (KSD). Herein, we implemented a two-sample bidirectional Mendelian randomization (MR) to investigate the causal relationship between IBD and KSD. Methods Data on IBD and KSD were obtained from Genome-Wide Association Studies (GWAS) summary statistics and the FinnGen consortium, respectively. Strict selection steps were used to screen for eligible instrumental SNPs. We applied inverse variance weighting (IVW) with the fix-effects model as the major method. Several sensitivity analyses were used to evaluate pleiotropy and heterogeneity. Causal relationships between IBD and KSD were explored in two opposite directions. Furthermore, we carried out multivariable MR (MVMR) to obtain the direct causal effects of IBD on KSD. Results Our results demonstrated that CD could increase the risk of KSD (IVW: OR = 1.06, 95% CI = 1.03-1.10, p < 0.001). Similar results were found in the validation group (IVW: OR = 1.05, 95% CI = 1.01-1.08, p = 0.013) and in the MVMR analysis. Meanwhile, no evidence of a causal association between UC and KSD was identified. The reverse MR analysis detected no causal association. Conclusions This MR study verified that CD plays a critical role in developing kidney stones and that the effect of UC on KSD needs to be further explored."

基金机构："We thank all patients who provided tissue samples and the UK Biobank, FinnGen and the IIBDGC consortium for making the data publicly available."

基金资助正文："We thank all patients who provided tissue samples and the UK Biobank, FinnGen and the IIBDGC consortium for making the data publicly available."