Analysis of the value of echocardiographic parameters in the early diagnosis of preterm infants with bronchopulmonary dysplasia

作者全名："Mao, L.; Wu, Y.; Shu, X.; Li, S.; Huang, L."

作者地址："[Mao, L.; Wu, Y.; Shu, X.; Li, S.] Chengdu Univ, Clin Med Coll, Dept Pediat, Chengdu, Peoples R China; [Mao, L.; Wu, Y.; Shu, X.; Li, S.] Chengdu Univ, Affiliated Hosp, Chengdu, Peoples R China; [Huang, L.] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neonatol,Childrens Hosp, Key Lab Child Dev & Disorders,Chongqing Key Lab Pe, Chongqing, Peoples R China"

通信作者："Mao, L (通讯作者)，Chengdu Univ, Clin Med Coll, Dept Pediat, Chengdu, Peoples R China.; Huang, L (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neonatol,Childrens Hosp, Key Lab Child Dev & Disorders,Chongqing Key Lab Pe, Chongqing, Peoples R China."

来源：EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001089946700013

JCR分区：Q2

影响因子：3.3

年份：2023

卷号：27

期号：17

开始页：7988

结束页：7996

文献类型：Article

关键词：Bronchopulmonary dysplasia; Echocardiography; Pulmonary hypertension; Cardiac function

摘要："OBJECTIVE: The objective of this study was to investigate the role of echocardiographic parameters in diagnosing bronchopulmonary dysplasia (BPD) in preterm infants.PATIENTS AND METHODS: Ninety preterm infants with a gestational age of less than 32 weeks and a weight less than 1.5 kg, admitted to the neonatal intensive care unit of the hospital between January 2020 and January 2021, were selected for the study. The study subjects were divided into two groups: a BPD group (54 cases, observation group) and a non-BPD group (36 cases, control group). The correlation between tricuspid regurgitation (TR) velocity and BPD was investigated by detecting the cardiac function of preterm infants in both groups using a color Doppler ultrasound diagnostic instrument and analyzing the cardiac ultrasound results. The early prediction efficiency of TR velocity (m/s) for BPD was evaluated using the receiver operator characteristic (ROC) curve.RESULTS: The incidence of patent ductus arteriosus (PDA) and pulmonary hypertension (PH) in the observation group was significantly higher than that in the control group. The levels of left ventricular ejection fraction (LVEF) and left ventricular shorting fraction (LVFS) were significantly lower than those in the control group (p < 0.05). The incidence of patent foramen ovale (PFO), atrial septal defect (ASD), and ventricular septal defect (VSD) in the observation group were not significantly different from the control group (p > 0.05). The proportion of tricuspid regurgitation in the observation group was significantly higher than that in the control group, and the TR velocity was significantly higher than that in the control group. The Spearman correlation analysis showed that TR velocity (m/s) was positively correlated to BPD severity (r = 0.379, p < 0.05). The area under the curve (AUC) for predicting BPD with TR velocity was 0.735. The sensitivity and specificity were 88.0% and 62.6%, respectively, when the TR velocity was 1.45 m/s.CONCLUSIONS: Echocardiography is useful for understanding the degree of impaired cardiac function in preterm infants and for early detection of PH, which may reduce the mortality rate to a certain extent. The risk of BPD is significantly increased when TR velocity is higher than 1.45 m/s."

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