Association between polyunsaturated fatty acid intake and the prevalence of erectile dysfunction: A cross-sectional analysis of the NHANES 2001-2004

作者全名："Huang, Yong; Wang, Yingying; Su, Huiyi; Wang, Hexi; Xu, Haoyu; Xu, Chengwei; Zhou, Fulin; Zhang, Yao"

作者地址："[Huang, Yong; Wang, Hexi; Xu, Haoyu; Xu, Chengwei; Zhou, Fulin; Zhang, Yao] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Peoples R China; [Wang, Yingying] People Hosp Jiulongpo Dist, Dept Oncol, Chongqing 400050, Peoples R China; [Su, Huiyi] Chongqing Med Univ, Dept Resp Med, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Zhang, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Peoples R China."

来源：LIPIDS IN HEALTH AND DISEASE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001090338300002

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Polyunsaturated fatty acids (PUFAs); Arachidonic acid (AA); Erectile dysfunction (ED); National Health and Nutrition Examination Survey (NHANES)

摘要："BackgroundPolyunsaturated fatty acids (PUFAs) have demonstrated significant therapeutic potential across a wide range of disease. The aim of this study was to investigate the potential impact of PUFA intake on the prevalence of erectile dysfunction (ED).MethodsThe study included a total of 3730 participants from the National Health and Nutrition Examination Survey (NHANES) 2001-2004. Univariate analysis, multivariate regression analysis, subgroup analysis and machine learning were utilized to explore the relationship of variables to ED. Dose response curves were constructed to observe the linear or nonlinear relationship between PUFA intake and the prevalence of ED. Propensity score matching (PSM) was used for sensitivity analysis. Finally, the potential mechanistic link between PUFA intake and ED was explored.ResultsThrough univariate and multivariate regression analysis results before and after PSM and XGBoost algorithm model results, arachidonic acid (AA) was chosen as the main research object. The consumption of AA was found to be associated with a decreased prevalence of ED under the fully adjusted model [OR = 0.33 (0.20, 0.56), P < 0.001]. The interaction between AA and education was found in the subgroup analysis. Dose-response curves indicated a linear negative correlation between AA intake and the prevalence of ED. The above results were confirmed in the data analysis after 1:1 PSM. In addition, AA intake was associated with a decrease in inflammatory biomarkers and homocysteine.ConclusionsThe results suggest that AA intake is negatively correlated with the prevalence of ED. Further, anti-inflammatory and anti-endothelial damage may play a role in this."

基金机构："The authors thank all the participants involved in this study and all the professionals and institutions that collected and counted the participants' information. In addition, thanks to SpringerNature Author Services for providing language editing services"

基金资助正文："The authors thank all the participants involved in this study and all the professionals and institutions that collected and counted the participants' information. In addition, thanks to SpringerNature Author Services for providing language editing services."