Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population

作者全名："Kadier, Kaisaierjiang; Dilixiati, Diliyaer; Ainiwaer, Aikeliyaer; Liu, Xiaozhu; Lu, Jiande; Liu, Pengfei; Ainiwan, Mierxiati; Yesitayi, Gulinazi; Ma, Xiang; Ma, Yitong"

作者地址："[Kadier, Kaisaierjiang; Ainiwaer, Aikeliyaer; Liu, Pengfei; Ainiwan, Mierxiati; Yesitayi, Gulinazi; Ma, Xiang; Ma, Yitong] Xinjiang Med Univ, Affiliated Hosp 1, Dept Cardiol, State Key Lab Pathogenesis Prevent & Treatment Hig, Urumqi, Peoples R China; [Dilixiati, Diliyaer; Lu, Jiande] Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Urumqi, Peoples R China; [Liu, Xiaozhu] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China"

通信作者："Ma, X; Ma, YT (通讯作者)，Xinjiang Med Univ, Affiliated Hosp 1, Dept Cardiol, State Key Lab Pathogenesis Prevent & Treatment Hig, Urumqi, Peoples R China."

来源：BMC PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001090354900001

JCR分区：Q2

影响因子：3.4

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Systemic immune-inflammation index; Sleep-related disorder; Obstructive sleep apnoea; Daytime sleepiness; Sleep problems; Sleep duration; NHANES

摘要："BackgroundThe association between sleep-related disorders and inflammation has been demonstrated in previous studies. The systemic immune-inflammation index (SII) is a novel inflammatory index based on leukocytes, but its relationship with sleep-related disorder is unclear. We aimed to investigate the relationship between sleep-related disorder and SII in a nationally representative nonhospitalized sample.MethodsData were obtained from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Exposure variables included self-reported sleep-related disorders, such as sleep duration, sleep problems, high risk of OSA, and daytime sleepiness. SII and other traditional markers of inflammation were considered as outcome variables, including platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Multiple linear regression models were employed to examine the correlation between sleep-related disorders and inflammatory markers. Subgroup interactions were analyzed using likelihood ratio tests, and nonlinear relationships were explored by fitting restricted cubic splines.ResultsA total of 8,505 participants were enrolled in this study. Overall, sleep-related disorders were found to have a stronger association with SII compared to the PLR and NLR. The results of multiple linear regression analysis revealed that participants who experienced sleep problems (beta: 21.421; 95% CI 1.484, 41.358), had symptoms of OSA (beta: 23.088; 95% CI 0.441, 45.735), and reported daytime sleepiness (beta: 30.320; 95% CI 5.851, 54.789) exhibited a positive association with higher SII. For the analysis of other inflammatory markers, we only found that daytime sleepiness was associated with increased NLR levels (beta: 0.081; 95% CI 0.002, 0.159).ConclusionSleep problems, symptoms of OSA, and daytime sleepiness were found to have a positive association with the SII in US adults. However, further prospective studies are necessary to establish whether there is a causal relationship between these factors."

基金机构：We thank all the staff of the National Health and Nutrition Examination Survey program for their efforts in data collection.

基金资助正文：We thank all the staff of the National Health and Nutrition Examination Survey program for their efforts in data collection.