The complex genetic landscape of southwestern Chinese populations contributed to their extensive ethnolinguistic diversity

作者全名："Wang, Mengge; Duan, Shuhan; Sun, Qiuxia; Liu, Yan; Tang, Renkuan; Yang, Junbao; Chen, Pengyu; Liu, Chao; Sun, Hongyu; He, Guanglin"

作者地址："[Wang, Mengge; Liu, Chao; Sun, Hongyu] Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou, Peoples R China; [Wang, Mengge] Guangzhou Forens Sci Inst, Guangzhou, Peoples R China; [Duan, Shuhan; Sun, Qiuxia; Liu, Yan; He, Guanglin] Sichuan Univ, Inst Rare Dis, West China Hosp, Chengdu, Peoples R China; [Duan, Shuhan; Liu, Yan; Yang, Junbao] North Sichuan Med Coll, Sch Basic Med Sci, Nanchong, Peoples R China; [Sun, Qiuxia; Tang, Renkuan] Chongqing Med Univ, Coll Basic Med, Dept Forens Med, Chongqing, Peoples R China; [Chen, Pengyu] Zunyi Med Univ, Ctr Forens Expertise, Affiliated Hosp, Zunyi, Guizhou, Peoples R China; [Liu, Chao] Antidrug Technol Ctr Guangdong Prov, Guangzhou, Peoples R China"

通信作者："Wang, MG; Liu, C; Sun, HY (通讯作者)，Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou, Peoples R China.; Wang, MG (通讯作者)，Guangzhou Forens Sci Inst, Guangzhou, Peoples R China.; He, GL (通讯作者)，Sichuan Univ, Inst Rare Dis, West China Hosp, Chengdu, Peoples R China.; Liu, C (通讯作者)，Antidrug Technol Ctr Guangdong Prov, Guangzhou, Peoples R China."

来源：FRONTIERS IN ECOLOGY AND EVOLUTION

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:001090361600001

JCR分区：Q2

影响因子：2.4

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ethnolinguistic diversity; genome-wide SNP; genetic diversity; admixture events; evolutionary history

摘要："The comprehensive characterization of the fine-scale genetic background of ethnolinguistically diverse populations can gain new insights into the population admixture processes, which is essential for evolutionary and medical genomic research. However, the genetic diversity and population history of southern Chinese indigenous people are underrepresented in human genetics research and their interaction with historical immigrants remains unknown. Here, we collected genome-wide SNP data from 20 Guizhou populations belonging to three primary language families [Tai-Kadai (TK), Hmong-Mien (HM), and Tibeto-Burman (TB)], including four groups newly collected here, and merged them with publicly available data from 218 modern and ancient East Asian groups to perform one comprehensive demographic and evolutionary history reconstruction. We comprehensively characterized the genetic signatures of geographically diverse populations and found language-related population stratification. We identified the unique HM genetic lineage in Southwest China and Southeast Asia as their shared ancestral component in the demographic history reconstruction. TK and TB people showed a differentiated genetic structure from HM people. Our identified admixture signals and times further supported the hypothesis that HM people originated from the Yungui Plateau and then migrated southward during the historical period. Admixture models focused on Sino-Tibetan and TK people supported their intense interaction, and these populations harbored the most extensive gene flows consistent with their shared linguistic and cultural characteristics and lifestyles. Estimates of identity-by-descent sharing and effective population size showed the extensive population stratification and gene flow events in different time scales. In short, we presented one complete landscape of the evolutionary history of ethnolinguistically different southern Chinese people and filled the gap of missing diversity in South China."

基金机构：This study was supported by the National Natural Science Foundation of China (NSFC 82202078). [NSFC 82202078]; National Natural Science Foundation of China

基金资助正文："We thank Prof. Etienne Patin at Institut Pasteur for sharing high-coverage whole-genome sequencing data from Taiwan Island, Island Southeast Asia and Oceania. We thank Prof. Wibhu Kutanan, Prof. Mark Stoneking, and Dr. Dang Liu for sharing genome-wide SNP data from Vietnam, Thailand, and Laos. We also thank all volunteers who participated in this project.r This study was supported by the National Natural Science Foundation of China (NSFC 82202078)."