HbA1c: an independent risk factor for dysthyroid optic neuropathy

作者全名："Wang, Xing; Ye, Huijing; Chen, Rongxin; Yang, Shenglan; Zhang, Te; Xiao, Wei; Yang, Huasheng"

作者地址："[Wang, Xing; Ye, Huijing; Chen, Rongxin; Yang, Shenglan; Zhang, Te; Xiao, Wei; Yang, Huasheng] Sun Yat sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou, Peoples R China; [Wang, Xing] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Dept Ophthalmol,Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China"

通信作者："Yang, HS (通讯作者)，Sun Yat sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001090437900001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：dysthyroid optic neuropathy; thyroid-associated ophthalmopathy; diabetes mellitus; HbA1c; risk factor

摘要："Background We aimed to explore the frequencies of islet beta-cell autoantibodies and insulin resistance (IR) in thyroid-associated ophthalmopathy (TAO) and identify specific diabetes mellitus (DM) indicators as early predictors for dysthyroid optic neuropathy (DON).Methods Ninety-eight TAO patients (57 DON and 41 non-DON patients) and 48 healthy control (HC) participants were recruited for this prospective cross-sectional study. Serum thyroxine, serum thyroid autoantibodies, serum humoral immune markers against islet beta-cell, fasting plasma glucose (FPG), fasting serum insulin (FINS), fasting c-peptide (FCP), and glycosylated hemoglobin A1 (HbA1c) were measured. Logistic regression analysis was used to evaluate the correlation of patients' age, body mass index (BMI), FPG, HbA1c, and related indexes of islet beta-cell function to the occurrence of DON.ResultsThe DON group had higher FPG (P<0.001, 0.016) and HbA1c (P<0.0001, P<0.001) levels than the HC and non-DON groups. The homeostasis model assessment (HOMA)-IR level was the highest in the DON group (HC 2.15 +/- 0.89, non-DON 2.41 +/- 1.24, and DON 2.82 +/- 2.65), while the HOMA-beta level was the lowest (HC 101.8 +/- 44.75%, non-DON 102.9 +/- 54.61%, and DON 88.29 +/- 52.75%), with no significant differences (P=1, P>0.05). On univariate analysis, age (P=0.006), BMI (P=0.022), history of steroid use (P=0.014), FPG (P=0.013), and HbA1c (P=0.001) levels were significantly associated with the presence/absence of DON. In addition, after adjusting for potential confounds, the HbA1c level was an independent factor associated with DON (P=0.009, OR=4.012).Conclusions HbA1c is an independent risk factor for DON. Given the interconnected link between thyroid dysfunction and DM, the use of HbA1c as a potential biomarker for DON warrants further investigation."

基金机构："This study was supported by the National Natural Science Foundation of China (81870689), the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (20211077), and the Fundamental Research Funds of the State Key Laborato [81870689]; National Natural Science Foundation of China [20211077]; Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine; Fundamental Research Funds of the State Key Laboratory of Ophthalmology"

基金资助正文："The authors thank Peng Wang, MD Ph.D. (Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China) for his help with the statistical analysis.r This study was supported by the National Natural Science Foundation of China (81870689), the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine (20211077), and the Fundamental Research Funds of the State Key Laboratory of Ophthalmology."