Pregnancy outcomes of adenomyotic patients with primary infertility after high-intensity focused ultrasound treatment

作者全名："Xiong, Li; Cheng, Wei; Wang, Zhibiao; Shi, Qiuling"

作者地址："[Xiong, Li; Wang, Zhibiao; Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Xiong, Li; Cheng, Wei] Hunan Prov Maternal & Child Hlth Care Hosp, Dept Gynaecol & Obstet, Changsha, Peoples R China; [Shi, Qiuling] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Wang, Zhibiao] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med & Engn, Chongqing 400016, Peoples R China; [Shi, Qiuling] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China"

通信作者："Wang, ZB (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med & Engn, Chongqing 400016, Peoples R China.; Shi, QL (通讯作者)，Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001090456900001

JCR分区：Q2

影响因子：3

年份：2023

卷号：40

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound (HIFU); pregnancy; adenomyosis; primary infertility

摘要："Objective To evaluate the therapeutic effect of high-intensity focused ultrasound (HIFU) treatment for adenomyotic patients with primary infertility and to explore the factors that affect the pregnancy outcomes.Materials and methods Twenty-seven adenomyotic patients with primary infertility who underwent HIFU at HUNAN Provincial Maternal and Child Health Care Hospital, China, between July 2018 and December 2022 were retrospectively reviewed. We evaluated the pregnancy outcomes and analyzed the factors that may affect pregnancy outcomes including time to conception, pregnancy approach, gestational age, delivery mode, neonatal outcomes, and complications during pregnancy and delivery.Results Among the 27 adenomyotic patients with primary infertility, 10 patients had a total of 11 pregnancies after HIFU treatment. Of these, eight (72%) cases were natural pregnancies and three (23%) were in vitro fertilization (IVF) pregnancies. The median time to conception was 10 (range 4-25) months. There were eight (72%) successful deliveries. The rate of full-term deliveries was 90%. Of the eight live births, four (50%) were born vaginally and four (50%) by cesarean section. No severe complications occurred. The mean birth weight of newborns was 3.1 (range: 2.3-3.9) kg; all newborns developed well without complications during postpartum and breastfeeding.Conclusions HIFU treatment for adenomyosis could improve fertility of patients with primary infertility. HIFU is a promising therapeutic approach for patients with adenomyosis and infertility who wish to achieve pregnancy and have live birth deliveries."

基金机构：Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering [2023KFKT012]

基金资助正文：This work was supported by Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering (Grant No.2023KFKT012)