Diagnostic value of contrast-enhanced ultrasonography in the preoperative evaluation of lymph node metastasis in papillary thyroid carcinoma: a single-center retrospective study

作者全名："Yang, Zhixin; Wang, Xiaofeng; Tao, Tao; Zou, Jiali; Qiu, Zhu; Wang, Long; Du, Huimin; Chen, Ni; Yin, Xuedong"

作者地址："[Yang, Zhixin; Zou, Jiali] Guiyang Maternal & Child Hlth Care Hosp, Guiyang Childrens Hosp, Dept Breast & Thyroid, Guiyang, Peoples R China; [Wang, Xiaofeng] Dongying Peoples Hosp, Dept Breast & Thyroid Surg, Dongying, Shandong, Peoples R China; [Qiu, Zhu] Chongqing Med Univ, Affiliated Hosp 1, Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China; [Tao, Tao; Wang, Long; Yin, Xuedong] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China; [Du, Huimin] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Chongqing, Peoples R China; [Chen, Ni] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Yin, XD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China.; Chen, N (通讯作者)，Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：BMC SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001090811700003

JCR分区：Q2

影响因子：1.9

年份：2023

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Papillary thyroid carcinoma; Contrast-enhanced ultrasound; Lymph node metastasis

摘要："Background Contrast-enhanced ultrasound (CEUS) has been recently used for the assessment of cervical lymph node metastasis (LNM) to guide surgical operation in patients with papillary thyroid carcinoma (PTC). However, the specificity and sensitivity of CEUS reported from previous studies are not consistent. The objective of this study was to evaluate the diagnostic value of CEUS for the metastasis of cervical lymph nodes in PTC patients based on data from one regional central hospital.Methods The diagnostic value of CEUS in preoperative LNM of PTC patients was concluded by comparing the results of CEUS on lymph node status with postoperative pathology examination. In addition, this study conducted hierarchical analysis of PTC patients to explore whether tumor size, different lymph node regions, and Hashimoto's thyroiditis influence the assessment of CEUS.Results This research study ultimately enrolled 965 PTC patients, including 266 males and 699 females with a mean age of 42.27 +/- 11.34 years. A total of 527 patients were considered clinical-node negative, and 438 were clinical-node positive before surgery. The specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CEUS in the assessment of LNM in PTC patients were 56.00%, 71.00%, 57.06%, 69.76% and 62.59%, respectively. For central and lateral lymph nodes, the accuracy of CEUS in PTC patients was 49.43% and 54.30%, respectively. In addition, it was shown that the accuracy of CEUS in PTC patients with Hashimoto's thyroiditis (HT) slightly decreased to 58.44%, and the accuracy of CEUS in PTC patients with non-HT in turn increased to 64.17%. The accuracy of CEUS in non-papillary thyroid microcarcinoma (PTMC) and PTMC patients was 65.68% and 61.24%, respectively. The accuracy of CEUS in predicting central LNM was significantly different between PTC patients with or without HT (P < 0.001) in this study but not for lateral lymph nodes (P = 0.114).Conclusion The accuracy of CEUS in the assessment of LNM in PTC is not consistently satisfactory, especially for central lymph nodes, small tumor diameters, or patients with HT. More diagnostic technologies for abnormal lymph nodes should be considered in PTC patients."

基金机构："The authors would like to thank all the surgeons who participated in the surgical operations of PTC patients, namely, Dr. Xinliang Su, Dr. Hongyuan Li, Dr. Shengchun Liu, and Dr. Xiaoyi Wang. The authors would like to thank all the pathologists who were in"

基金资助正文："The authors would like to thank all the surgeons who participated in the surgical operations of PTC patients, namely, Dr. Xinliang Su, Dr. Hongyuan Li, Dr. Shengchun Liu, and Dr. Xiaoyi Wang. The authors would like to thank all the pathologists who were involved in the diagnosis of PTC and LNM in this study, namely, Dr. Yaying Yang, Dr. Xiaoqin Guan and Dr. Shanshan Yu. In addition, the authors would like to thank all the medical ultrasound doctors who participated in the CEUS examination for PTC patients, namely, Dr. Chong Zhong and Dr. Yong Zhang."