"Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms"

作者全名："Zhang, Ting; Li, Jun; Li, Xi; Liu, Yanjun"

作者地址："[Zhang, Ting; Liu, Yanjun] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Gen Surg,Ctr Obes & Metab Dis, Chengdu, Peoples R China; [Zhang, Ting; Li, Jun; Liu, Yanjun] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu, Peoples R China; [Zhang, Ting; Liu, Yanjun] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Ctr Gastrointestinal & Minimally Invas Surg,Dept G, Chengdu, Peoples R China; [Zhang, Ting] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Med Res Ctr, Chengdu, Peoples R China; [Li, Jun] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Orthoped, Chengdu, Peoples R China; [Li, Xi] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China"

通信作者："Liu, YJ (通讯作者)，Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Gen Surg,Ctr Obes & Metab Dis, Chengdu, Peoples R China.; Liu, YJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu, Peoples R China.; Liu, YJ (通讯作者)，Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Ctr Gastrointestinal & Minimally Invas Surg,Dept G, Chengdu, Peoples R China.; Li, X (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001091127700001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：intermuscular adipose tissue; obesity; insulin resistance; intermuscular adipogenesis; therapeutic strategy

摘要："Intermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease, such as obesity and type 2 diabetes. Moreover, IMAT aggravates obesity-related muscle metabolism disorders via secretory factors. Interestingly, researchers have discovered that intermuscular brown adipocytes in rodent models provide new hope for obesity treatment by acting on energy dissipation, which inspired researchers to explore the underlying regulation of IMAT formation. However, the molecular and cellular properties and regulatory processes of IMAT remain debated. Previous studies have suggested that muscle-derived stem/progenitor cells and other adipose tissue progenitors contribute to the development of IMAT. Adipocytes within IMAT exhibit features that are similar to either white adipocytes or uncoupling protein 1 (UCP1)-positive brown adipocytes. Additionally, given the heterogeneity of skeletal muscle, which comprises myofibers, satellite cells, and resident mesenchymal progenitors, it is plausible that interplay between these cellular components actively participate in the regulation of intermuscular adipogenesis. In this context, we review recent studies associated with IMAT to offer insights into the cellular origins, biological properties, and regulatory mechanisms of IMAT. Our aim is to provide novel ideas for the therapeutic strategy of IMAT and the development of new drugs targeting IMAT-related metabolic diseases."

基金机构："The author(s) declare financial support was received for the research, authorship, and/or publication of this article."

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article."