Time-restricted feeding alleviates metabolic implications of circadian disruption by regulating gut hormone release and brown fat activation

作者全名："Chi, Sensen; Zhang, Taoyuan; Pan, Yu; Niu, Shenghui; Zhao, Lin; Gu, Zili; Liu, Qi; Jin, Aishun; Wang, Wang; Tan, Shuai"

作者地址："[Chi, Sensen; Zhang, Taoyuan; Pan, Yu; Jin, Aishun; Wang, Wang; Tan, Shuai] Chongqing Med Univ, Sch Basic Med Sci, Dept Immunol, Chongqing 400010, Peoples R China; [Niu, Shenghui; Zhao, Lin] Sichuan Univ, West China Univ Hosp 2, Dept Paediat, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu 610041, Peoples R China; [Niu, Shenghui; Zhao, Lin] Sichuan Univ, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China; [Gu, Zili] Leiden Univ, Dept Radiol, Med Ctr, NL-2333 ZA Leiden, Netherlands; [Liu, Qi; Tan, Shuai] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX 75390 USA"

通信作者："Jin, AS; Wang, W; Tan, S (通讯作者)，Chongqing Med Univ, Sch Basic Med Sci, Dept Immunol, Chongqing 400010, Peoples R China."

来源：FOOD & FUNCTION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001091564700001

JCR分区：Q1

影响因子：5.1

年份：2023

卷号：　

期号：　

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文献类型：Article; Early Access

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摘要："Individuals with rotating and night shift work are highly susceptible to developing metabolic disorders such as obesity and diabetes. This is primarily attributed to disruptions in the circadian rhythms caused by activities and irregular eating habits. Time-restricted feeding (tRF) limits the daily eating schedules and has been demonstrated to markedly improve several metabolic disorders. Although an intricate relationship exists between tRF and circadian rhythms, the underlying specific mechanism remains elusive. We used a sleep disruption device for activity interference and established a model of circadian rhythm disorder in mice with different genetic backgrounds. We found that circadian rhythm disruption led to abnormal hormone secretion in the gut and elevated insulin resistance. tRF improved metabolic abnormalities caused by circadian rhythm disruption, primarily by restoring the gut hormone secretion rhythm and activating brown fat thermogenesis. The crucial function of brown fat in tRF was confirmed using a mouse model with brown fat removal. We demonstrated that chenodeoxycholic acid (CDCA) effectively improved circadian rhythm disruption-induced metabolic disorders by restoring brown fat activation. Our findings demonstrate the potential benefits of CDCA in reversing metabolic disadvantages associated with irregular circadian rhythms. Scheme of the study. Time-restricted feeding may alleviate metabolic implications caused by circadian disruption through regulating the circadian of gut hormone release and activating thermogenesis from brown fat."

基金机构："This work is supported by the Science and Technology Project Affiliated with the Education Department of Chongqing Municipality (KJQN2021043), and by the Natural Science Foundation by Chongqing (CSTB2022NSCQ-MSX1027). [KJQN2021043]; Science and Technology Project Affiliated with the Education Department of Chongqing Municipality [CSTB2022NSCQ-MSX1027]; Natural Science Foundation by Chongqing"

基金资助正文："This work is supported by the Science and Technology Project Affiliated with the Education Department of Chongqing Municipality (KJQN2021043), and by the Natural Science Foundation by Chongqing (CSTB2022NSCQ-MSX1027)."