Potential application of peripheral blood biomarkers in intracranial aneurysms

作者全名："Wu, Yangying; Zhao, Ziya; Kang, Shaolei; Zhang, Lijuan; Lv, Fajin"

作者地址："[Wu, Yangying; Zhao, Ziya; Kang, Shaolei; Zhang, Lijuan; Lv, Fajin] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Kang, Shaolei] Kunming Med Univ, Affiliated Hosp 1, Dept Med Imaging, Kunming, Peoples R China"

通信作者："Lv, FJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001091829000001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：blood biomarker; intracranial aneurysm; inflammation; cytokine; blood lipid

摘要："Intracranial aneurysm (IA) counts are increasing yearly, with a high mortality and disability after rupture. Current diagnosis and treatment rely on costly equipment, lacking effective indicators for progression prediction and specific drugs for treatment. Recently, peripheral blood biomarkers, as common clinical test samples, reflecting the immune and inflammatory state of the body in real-time, have shown promise in providing additional information for risk stratification and treatment in IA patients, which may improve their outcomes after aneurysm rupture through anti-inflammatory therapy. Therefore, this paper reviewed the progress of potential biomarkers of IAs, including inflammatory blood indicators, cytokines, and blood lipids, aiming to aid individual management and therapy of aneurysms in clinical practices."

基金机构："The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article."

基金资助正文："We would like to express our sincere gratitude to the individuals who generously provided their expertise and suggestions for the completion of this review.r The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article."