CEP55 as a Promising Immune Intervention Marker to Regulate Tumor Progression: A Pan-Cancer Analysis with Experimental Verification

作者全名："Wang, Gang; Chen, Bo; Su, Yue; Qu, Na; Zhou, Duanfang; Zhou, Weiying"

作者地址："[Wang, Gang; Chen, Bo; Su, Yue; Qu, Na; Zhou, Duanfang; Zhou, Weiying] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing 400016, Peoples R China; [Wang, Gang; Chen, Bo; Su, Yue; Qu, Na; Zhou, Duanfang; Zhou, Weiying] Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing 400016, Peoples R China; [Wang, Gang; Chen, Bo; Su, Yue; Qu, Na; Zhou, Duanfang; Zhou, Weiying] Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing 400016, Peoples R China"

通信作者："Zhou, WY (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing 400016, Peoples R China.; Zhou, WY (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing 400016, Peoples R China.; Zhou, WY (通讯作者)，Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing 400016, Peoples R China."

来源：CELLS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001092423500001

JCR分区：Q2

影响因子：5.1

年份：2023

卷号：12

期号：20

开始页：　

结束页：　

文献类型：Article

关键词：pan-cancer; centrosomal proteins 55; tumor progression; immune infiltration; CD-437

摘要："CEP55, a member of the centrosomal protein family, affects cell mitosis and promotes the progression of several malignancies. However, the relationship between CEP55 expression levels and prognosis, as well as their role in cancer progression and immune infiltration in different cancer types, remains unclear. We used a combined form of several databases to validate the expression of CEP55 in pan-cancer and its association with immune infiltration, and we further screened its targeted inhibitors with CEP55. Our results showed the expression of CEP55 was significantly higher in most tumors than in the corresponding normal tissues, and it correlated with the pathological grade and age of the patients and affected the prognosis. In breast cancer cells, CEP55 knockdown significantly decreased cell survival, proliferation, and migration, while overexpression of CEP55 significantly promoted breast cancer cell proliferation and migration. Moreover, CEP55 expression was positively correlated with immune cell infiltration, immune checkpoints, and immune-related genes in the tumor microenvironment. CD-437 was screened as a potential CEP55-targeted small-molecule compound inhibitor. In conclusion, our study highlights the prognostic value of CEP55 in cancer and further provides a potential target selection for CEP55 as a potential target for intervention in tumor immune infiltration and related immune genes."

基金机构："We sincerely acknowledge the contributions of the Sangerbox platform (<uri>http://sangerbox.com/</uri> accessed on 19 December 2022) in assisting with data analysis and figure plotting. Finally, we also acknowledge the contribution of all free public datab"

基金资助正文："We sincerely acknowledge the contributions of the Sangerbox platform (<URI>http://sangerbox.com/</URI> accessed on 19 December 2022) in assisting with data analysis and figure plotting. Finally, we also acknowledge the contribution of all free public databases and analysis platforms mentioned in this article."