NKG2D receptor regulates CD4+T cell differentiation<i> via</i> interaction with dendritic cells in patients with juvenile idiopathic arthritis

作者全名："Zhou, Juan; Wang, Junyan; Tao, Linlin; Liu, Mingyue; Tang, Xuemei; Zhu, Xiaoping"

作者地址："[Zhou, Juan] Prov Clin Res Ctr Child Hlth, Guangzhou Women & Childrens Med Ctr, Dept Pediat Allergy Immunol & Rheumatol, Guangzhou, Guangdong, Peoples R China; [Liu, Mingyue] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Immunol,Minist Educ,Key Lab Child Dev & Disor, Chongqing, Peoples R China; [Zhu, Xiaoping] Guizhou Med Univ, Affiliated Hosp, Med Ctr Children Guizhou Prov, Dept Pediat, Guiyang, Peoples R China; [Zhu, Xiaoping] Guizhou Med Univ, Affiliated Hosp, Dept Pediat, 28 Guiyi St, Guiyang, Peoples R China"

通信作者："Zhu, XP (通讯作者)，Guizhou Med Univ, Affiliated Hosp, Dept Pediat, 28 Guiyi St, Guiyang, Peoples R China."

来源：CLINICAL IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001092835600001

JCR分区：Q2

影响因子：4.5

年份：2023

卷号：256

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：NKG2D; Juvenile idiopathic arthritis; CD4+T cell; Differentiation; Dendritic cell

摘要："NKG2D provides a costimulatory signal for activation of CD4+ T cells. We explored its role in interactions of CD4+ T cells and dendritic cells (DCs) in juvenile idiopathic arthritis (JIA) patients by using NKG2D genetically modified CD4+ T cells. We found active JIA patients had significantly higher content of CD4 + NKG2D+ T cells than healthy controls. Expression of NKG2D on CD4+ T cells, and MICA and MICB on DCs were significantly greater in articular JIA than systemic JIA. NKG2D induced IL-12 and suppressed IL-10 and TGF-beta from CD4+ T cells, increased IFN-gamma + CD4+ T and IL-17+ CD4+ T cells, RORc and T-bet, but reduced CD25+ Foxp3+ CD4+ T cells, IL-4+ CD4+ T cells, Foxp3, and GATA3 in JIA patients. NKG2D decreased IL-10 and increased CD83, MICA, and MICB of DCs in JIA and controls. So NKG2D regulates differentiation of CD4+ T cells directly and the maturation of DCs indirectly."

基金机构："National Key Research and Development Program of China [2021YFC2702003]; Chongqing Science and Technology Commission; Chongqing Yuzhong Science and Technology [20210136]; Program for Youth Innovation in Future Medicine, Chongqing Medical [W0114]; Social Development Project of the Science and Technology Department of Guizhou Province [Qiankehe Foundation] [(2020)4Y124]"

基金资助正文："This work was supported by National Key Research and Development Program of China(2021YFC2702003), the Chongqing Science and Technology Commission, and the Chongqing Yuzhong Science and Technology (20210136), the Program for Youth Innovation in Future Medicine, Chongqing Medical (W0114) and The Social Development Project of the Science and Technology Department of Guizhou Province [Qiankehe Foundation (2020)4Y124]."