Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/ 2-P90rsk-BAD ignaling pathway

作者全名："Pei, Caixia; Jia, Nan; Wang, Yilan; Zhao, Sijing; Shen, Zherui; Shi, Shihua; Huang, Demei; Wu, Yongcan; Wang, Xiaomin; Li, Shuiqin; He, Yacong; Wang, Zhenxing"

作者地址："[Pei, Caixia; Jia, Nan; Wang, Yilan; Zhao, Sijing; Shen, Zherui; Shi, Shihua; Huang, Demei; Wang, Xiaomin; Li, Shuiqin; Wang, Zhenxing] Hosp Chengdu Univ Tradit Chinese Med, Dept Oncol, 39 Shi Er Qiao Rd, Chengdu 610075, Sichuan, Peoples R China; [Wu, Yongcan] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Wu, Yongcan] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China; [He, Yacong] Chengdu Univ Tradit Chinese Med, Sch Pharm, 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China; [He, Yacong] Chengdu Univ Tradit Chinese Med, 1166 Liutai Ave, Chengdu 611137, Peoples R China; [Wang, Zhenxing] Hosp Chengdu Univ Tradit Chinese Med, Dept Gynecol, Chengdu, Peoples R China"

通信作者："Wang, ZX (通讯作者)，Hosp Chengdu Univ Tradit Chinese Med, Dept Oncol, 39 Shi Er Qiao Rd, Chengdu 610075, Sichuan, Peoples R China.; He, YC (通讯作者)，Chengdu Univ Tradit Chinese Med, Sch Pharm, 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China.; He, YC (通讯作者)，Chengdu Univ Tradit Chinese Med, 1166 Liutai Ave, Chengdu 611137, Peoples R China.; Wang, ZX (通讯作者)，Hosp Chengdu Univ Tradit Chinese Med, Dept Gynecol, Chengdu, Peoples R China."

来源：EUROPEAN JOURNAL OF PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001094745400001

JCR分区：Q1

影响因子：4.2

年份：2023

卷号：959

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：High-altitude pulmonary edema; Notoginsenoside R1; Apoptosis; ERK1/2; Inflammation

摘要："High-altitude pulmonary edema (HAPE) is a potentially fatal disease. Notoginsenoside R1 is a novel phytoestrogen with anti-inflammatory, antioxidant and anti-apoptosis properties. However, its effects and underlying mechanisms in the protection of hypobaric hypoxia-induced HAPE rats remains unclear. This study aimed to explore the protective effects and underlying mechanisms of Notoginsenoside R1 in hypobaric hypoxia-induced HAPE. We found that Notoginsenoside R1 alleviated the lung tissue injury, decreased lung wet/dry ratio, and reduced inflammation and oxidative stress. Additionally, Notoginsenoside R1 ameliorated the changes in arterial blood gas, decreased the total protein concentration in bronchoalveolar lavage fluid, and inhibited the occurrence of apoptosis caused by HAPE. In the process of further exploration of the mechanism, it was found that Notoginsenoside R1 could promote the activation of ERK1/2-P90rsk-BAD signaling pathway, and the effect of Notoginsenoside R1 was attenuated after the use of ERK1/2 inhibitor U0126. Our study indicated that the protective effects of Notoginsenoside R1 against HAPE were mainly related to the inhibition of inflammation, oxidative stress, and apoptosis. Notoginsenoside R1 may be a potential candidate for preventing HAPE."

基金机构："National Natural Science Founda-tion of China [82205043]; China Postdoctoral Science Founda-tion [2022M710500, YJ20220058]; Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine [2023MS555]"

基金资助正文："This study was supported by the National Natural Science Founda-tion of China (No. 82205043) , the China Postdoctoral Science Founda-tion (No. 2022M710500 and No. YJ20220058) , and the Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine (No. 2023MS555) ."