"Histological, Physiological and Biomechanical Effects of Low-Level Laser Therapy on Tendon Healing in Animals and Humans: A Systematic Review"

作者全名："He, Kexu; Zhou, Xuelian; Zheng, Feisheng; Ju, Xiaojie; Fu, Siu-Ngor; Wong, Arnold Y. L."

作者地址："[He, Kexu; Zhou, Xuelian; Zheng, Feisheng; Ju, Xiaojie; Fu, Siu-Ngor; Wong, Arnold Y. L.] Hong Kong Polytech Univ, Dept Rehabil Sci, Hung Hom, Hong Kong, Peoples R China; [He, Kexu] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing, Peoples R China"

通信作者："Wong, AYL (通讯作者)，Hong Kong Polytech Univ, Dept Rehabil Sci, Hung Hom, Hong Kong, Peoples R China."

来源：ANNALS OF BIOMEDICAL ENGINEERING

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001095049700002

JCR分区：Q3

影响因子：3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Tendon injury; Tendinopathy; Low-level laser therapy; Histological effects; Physiological effects; Biomechanical effects

摘要："Low-level Laser Therapy (LLLT) was widely used in clinical practice for tendon disorders. However, the underlying mechanisms and effectiveness of LLLT in treating tendon injury remain unclear. Therefore, the present study was conducted aiming to summarize the evidence regarding the histological, physiological, and biomechanical effects of LLLT on tendon healing in animal and human models. Four databases were searched for relevant literature. Four independent reviewers screened abstracts and full-text articles, extracted relevant data, evaluated the risk of bias, and quantified the quality of evidence. Database searches yielded 1400 non-duplicated citations. Fifty-five studies were included (50 animal and five human studies). Animal studies revealed that LT had stimulating effects on collagen organization, collagen I and collagen II formation, matrix metalloproteinase (MMP)-8, transforming growth factor beta 1, vascular endothelial growth factor, hydroxyproline, maximum load, maximum elongation before breaking, and tendon stiffness. However, LLLT had inhibitory effects on the number of inflammatory cells, histological scores, relative amount of collagen III, cyclooxygenase-2, prostaglandin E2 (PGE2), interleukin-6, tumor necrosis factor-alpha, MMP-1, and MMP-3. Although one human study found that LLLT reduced the concentration of PGE2 in peritendinous tissue of the Achilles tendon, other human studies revealed that the effects of LLLT on the physiology and biomechanics of human tendons remained uncertain. LLLT facilitates tendon healing through various histological, physiological, and biomechanical effects in animal models. Only post-LLLT anti-inflammatory effects were found in human studies."

基金机构：　

基金资助正文：